{"id":128908,"date":"1996-01-01T00:00:00","date_gmt":"1996-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-potenciador-de-la-citotoxicidad-de-anticancerosos-por-modificacion-farmacologica-del-ph-intracelular-en-hepatomas-en-cultivo\/"},"modified":"1996-01-01T00:00:00","modified_gmt":"1996-01-01T00:00:00","slug":"efecto-potenciador-de-la-citotoxicidad-de-anticancerosos-por-modificacion-farmacologica-del-ph-intracelular-en-hepatomas-en-cultivo","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/efecto-potenciador-de-la-citotoxicidad-de-anticancerosos-por-modificacion-farmacologica-del-ph-intracelular-en-hepatomas-en-cultivo\/","title":{"rendered":"Efecto potenciador de la citotoxicidad de anticancerosos por modificacion farmacologica del ph intracelular en hepatomas en cultivo."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Perez De Diego Javier <\/strong><\/h2>\n<p>Se trata del estudio de acidificantes intracelulares, que inhiban especificamente la actividad del antiportador na+:h+ de celulas de hepatocarcinoma de rata \u00abin vitro\u00bb, analizando el papel de este transportador en la homeostasis del ph intracelular en esta linea tumoral, y el efecto potenciador sobre la accion citotoxica ejercida por el anticanceroso doxorubicina.Igualmente, se analizan los efectos de la acidificacion sobre la redistribucion de esta droga inducidos por el inhibidor del antiportador amiloride, a nivel de la expresion y mecanismo de transporte de la proteina producto del gen de multirresistencia a drogas, mdr, y el papel que ejerce sobre otros aspectos asociados a este fenotipo, como son los mecanismos de conjugacion ligados a glutation y enzimas asociados, con el proposito de utilizar la via de modificacion farmacologica del ph, como una posible via de quimioterapia coadyuvante del cancer y establecer, al mismo tiempo, un modelo para el estudio de nuevas vias en el tratamiento de los tumores de higado en humanos.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto potenciador de la citotoxicidad de anticancerosos por modificacion farmacologica del ph intracelular en hepatomas en cultivo.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto potenciador de la citotoxicidad de anticancerosos por modificacion farmacologica del ph intracelular en hepatomas en cultivo. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Perez De Diego Javier <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1996<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Rafael Garcia Ca\u00f1ero<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Manuel Roman Benito De Las Heras <\/li>\n<li>Miguel Quintanilla Avila (vocal)<\/li>\n<li>Santiago Ramon Y Cajal Ag\u00ed\u00bceras (vocal)<\/li>\n<li> Diaz Gil Juan  Jos\u00e9 (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Perez De Diego Javier Se trata del estudio de acidificantes intracelulares, que inhiban especificamente la actividad del [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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