{"id":129110,"date":"1996-01-01T00:00:00","date_gmt":"1996-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-las-alteraciones-en-k-ras-c-myc-y-p53-como-factores-pronostico-en-cancer-colo-rectal-y-no-microcitico-de-pulmon\/"},"modified":"1996-01-01T00:00:00","modified_gmt":"1996-01-01T00:00:00","slug":"estudio-de-las-alteraciones-en-k-ras-c-myc-y-p53-como-factores-pronostico-en-cancer-colo-rectal-y-no-microcitico-de-pulmon","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/estudio-de-las-alteraciones-en-k-ras-c-myc-y-p53-como-factores-pronostico-en-cancer-colo-rectal-y-no-microcitico-de-pulmon\/","title":{"rendered":"Estudio de las alteraciones en k-ras, c-myc y p53 como factores pronostico en cancer colo-rectal y no microcitico de pulmon."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Vega Alonso Francisco Jose <\/strong><\/h2>\n<p>Este trabajo constituye un estudio prospectivo realizado en 74 adenocarcinomas colo-rectales primarios y en 100 carcinomas primarios de no peque\u00f1a celula de pulmon, procedentes de pacientes intervenidos quirurgicamente de estas patolog\u00edas. El principal objetivoha sido el establecimiento de factores pronostico de tipo oncogenico en estos pacientes, con el fin de seleccionar grupos de alto riesgo para contribuir al dise\u00f1o de protocolos terapeuticos mas eficientes. Para ello, se han analizado alteraciones en los oncogenes k-ras y c-myc, asi como a nivel de la proteina y del gen supresor p53, y se ha realizado un seguimiento adecuado de los pacientes incluidos en los protocolos. Las alteraciones oncogenicas se han relacionado con distintos parametros histologicos de los tumores y con la supervivencia de los pacientes.  como principales conclusiones hay que destacar que las mutaciones puntuales tipo transversion en el codon 12 de k-ras confieren una menor supervivencia tanto en cancer colo-rectal como en cancer no microcitico de pulmon. Las mutaciones puntuales en p53, y fundamentalmente las localizadas en el exon 5, constituyen un indicador de mal pronostico en cancer no microcitico de pulmon.  finalmente, la sobre expresion del rnam de c-myc carece de valor pronostico en ambas patolog\u00edas.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de las alteraciones en k-ras, c-myc y p53 como factores pronostico en cancer colo-rectal y no microcitico de pulmon.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de las alteraciones en k-ras, c-myc y p53 como factores pronostico en cancer colo-rectal y no microcitico de pulmon. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Vega Alonso Francisco Jose <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1996<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Iniesta Serrano Mar\u00eda Pilar<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Eduardo D\u00edaz-rubio Garc\u00eda <\/li>\n<li>Miguel Angel Peinado Morales (vocal)<\/li>\n<li>Trinidad Caldes Llopis (vocal)<\/li>\n<li>Antonio  Jos\u00e9 Torres Garc\u00eda (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Vega Alonso Francisco Jose Este trabajo constituye un estudio prospectivo realizado en 74 adenocarcinomas colo-rectales primarios y [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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