{"id":129121,"date":"1996-01-01T00:00:00","date_gmt":"1996-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/activacion-del-linfocito-t-en-el-anciano-coestimulacion-por-el-receptor-cd28\/"},"modified":"1996-01-01T00:00:00","modified_gmt":"1996-01-01T00:00:00","slug":"activacion-del-linfocito-t-en-el-anciano-coestimulacion-por-el-receptor-cd28","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/activacion-del-linfocito-t-en-el-anciano-coestimulacion-por-el-receptor-cd28\/","title":{"rendered":"Activacion del linfocito t en el anciano: coestimulacion por el receptor cd28."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Vidan Astiz M. Teresa <\/strong><\/h2>\n<p>El envejecimiento se asocia a un deterioro de la respuesta e inmune tanto humoral como celular. El componente del sistema inmune principalmente afectado por la edad es el linfocito t, que presenta diversas alteraciones en su proceso de activacion.  para una correcta activacion del linfocito t son necesarias dos se\u00f1ales: una de ellas se produce por el contacto del antigeno con su receptor especifico en la superficie de la celula t, y la otra viene dada por una molecula coestimuladora. Cd28 es un receptor de la superficie del linfocito t que aporta una de las principales se\u00f1ales de coestimulo. Su funcionamiento en relacion al envejecimiento no se conoce apenas. En este estudio analizamos su expresion y funcion en los linfocitos t del anciano, comprobando que ambas aparecen preservadas en la edad avanzada. La utilizacion del coestimulo via cd28 in vitro fue capaz de corregir el efecto de proliferacion que presentaban los linfocitos del anciano al ser estimulados a traves de cd3 (via del antigeno). Ademas el estimulo del receptor cd28 induce una correcta secrecion de il-2, asi como una buena expresion de su receptor en los linfocitos del anciano.  por lo tanto esta via de coestimulacion t, al contrario que otras vias de estimulo, no se altera con el proceso de envejecimiento.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Activacion del linfocito t en el anciano: coestimulacion por el receptor cd28.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Activacion del linfocito t en el anciano: coestimulacion por el receptor cd28. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Vidan Astiz M. Teresa <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1996<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Manuel Ribera Casado<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Arturo Fern\u00e1ndez-cruz P\u00e9rez <\/li>\n<li>Antonio Lorenzo Pe\u00f1uelas (vocal)<\/li>\n<li>Carlos Martinez Manzanares (vocal)<\/li>\n<li>Juan  Jos\u00e9 Picazo De La Garza (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Vidan Astiz M. Teresa El envejecimiento se asocia a un deterioro de la respuesta e inmune tanto [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[155,9,986,8607,450,156],"tags":[1615,1777,1664,22803,3475,242508],"class_list":["post-129121","post","type-post","status-publish","format-standard","hentry","category-ciencias-clinicas","category-ciencias-medicas","category-complutense-de-madrid","category-geriatria","category-inmunopatologia","category-patologia","tag-antonio-lorenzo-penuelas","tag-arturo-fernandez-cruz-perez","tag-carlos-Martinez-manzanares","tag-jose-manuel-ribera-casado","tag-juan-jose-picazo-de-la-garza","tag-vidan-astiz-m-teresa"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/129121","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=129121"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/129121\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=129121"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=129121"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=129121"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}