{"id":129363,"date":"1996-01-01T00:00:00","date_gmt":"1996-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-comparativo-de-la-toxicidad-de-diversos-agentes-sobre-lineas-de-melanomas-de-raton-b16f10-y-humanas-sk-mel-28-y-sk-mel-1\/"},"modified":"1996-01-01T00:00:00","modified_gmt":"1996-01-01T00:00:00","slug":"estudio-comparativo-de-la-toxicidad-de-diversos-agentes-sobre-lineas-de-melanomas-de-raton-b16f10-y-humanas-sk-mel-28-y-sk-mel-1","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-comparativo-de-la-toxicidad-de-diversos-agentes-sobre-lineas-de-melanomas-de-raton-b16f10-y-humanas-sk-mel-28-y-sk-mel-1\/","title":{"rendered":"Estudio comparativo de la toxicidad de diversos agentes sobre lineas de melanomas de raton (b16f10) y humanas (sk-mel-28 y sk-mel-1)."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jose Rodriguez Vicente <\/strong><\/h2>\n<p>El melanoma muestra una incidencia en aumento, una evolucion incierta y una elevada mortalidad. Sin embargo, es muy resistente a la quimioterapia. Por lo que nos planteamos diversos tratamientos en tres lineas  de melanoma resistentes a los alquilantes. Utilizamos melfalan, ccnu, fotemustina y 4-hidroxianisol (4-ha), solos o sus combinaciones, y como sensibilizantes la butionil sulfoximina (bso), acido etacrinico (ea) y acido azelaico (aza), solos o seguidos de los antineoplasicos.  realizamos el estudio de la respuesta a estos tratamientos mediante ensayos con mtt resultando que: &#8211; la linea b16f10 era la mas sensible, seguida de la sk-mel-28, siendo la sk-me1-1 la mas resistente a todos los tratamientos. &#8211; Bso, ea y aza mostraban actividad antineoplasica. &#8211; El pretratamiento con los sensibilizantes a bajas concentraciones mejoraba mucho la actividad de los antineoplasicos, mucho mas incluso que sus combinaciones. &#8211; Observamos relacion entre el nivel de actividad dopa-oxidasa y la toxicidad del 4-ha en cada linea. &#8211; Las alteraciones morfologicas y ultraestructurales (barrido y transmision) de las celulas tratadas corresponden a fenomenos de injuria celular, que para el ea y aza se acompa\u00f1aban ademas de alteraciones especificas.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio comparativo de la toxicidad de diversos agentes sobre lineas de melanomas de raton (b16f10) y humanas (sk-mel-28 y sk-mel-1).<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio comparativo de la toxicidad de diversos agentes sobre lineas de melanomas de raton (b16f10) y humanas (sk-mel-28 y sk-mel-1). <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jose Rodriguez Vicente <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Murcia<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1996<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Manuel Canteras Jordana<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Blanca Agulleiro Diaz <\/li>\n<li> Miranda Leon M. Teresa (vocal)<\/li>\n<li>Guzman Ortu\u00f1o Pacheco (vocal)<\/li>\n<li>Miguel Angel Martorell Cebollada (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jose Rodriguez Vicente El melanoma muestra una incidencia en aumento, una evolucion incierta y una elevada mortalidad. [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,52,8235,156],"tags":[8451,25200,242733,8239,12210,35482],"class_list":["post-129363","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-histopatologia","category-murcia","category-patologia","tag-blanca-agulleiro-diaz","tag-guzman-ortuno-pacheco","tag-jose-rodriguez-vicente","tag-manuel-canteras-jordana","tag-miguel-angel-martorell-cebollada","tag-miranda-leon-m-teresa"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/129363","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=129363"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/129363\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=129363"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=129363"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=129363"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}