{"id":129429,"date":"1996-01-01T00:00:00","date_gmt":"1996-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/la-citoquina-tnf-alfa\/"},"modified":"1996-01-01T00:00:00","modified_gmt":"1996-01-01T00:00:00","slug":"la-citoquina-tnf-alfa","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/la-citoquina-tnf-alfa\/","title":{"rendered":"La citoquina tnf alfa."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Estefania Claudio Vazquez <\/strong><\/h2>\n<p>El tnf alfa es una citoquina sintetizada por una gran variedad de tipos celulares en respuesta a diversos estimulos externos. Ha sido originalmente caracterizada por su actividad anti-tumoral aunque posteriormente se ha visto implicada en numerosas actividades biologicas, como por ejemplo la reaccion inflamatoria y la reorganizacion de tejidos. La accion del tnf alfa varia mucho dependiendo del tipo celular sobre el que actue.  en la patogenesis de la silicosis, se piensa que la fagocitosis de las particulas de silice por los macrofagos produce una reaccion inflamatoria que conlleva la proliferacion de fibroblastos, los cuales simultaneamente producen componentes de la matriz extracelular, caracteristico del desarrollo de la fibrosis.  hemos establecido las condiciones de activacion de macrofagos \u00abin vitro\u00bb por la fagocitosis de particulas de silice despues de 48 h en unas condiciones donde el da\u00f1o celular es minimo. La activacion de macrofagos se determino mediante el analisis de la produccion de no2 y de tnf alfa. Ademas se ha estudiado el efecto biologico del tnf alfa sobre varias lineas celulares de forma que se puede establecer una relaccion entre respuesta citotoxica y origen tumoral de las celulas.  el tnf alfa lleva a cabo su accion a traves de dos receptores de membrana que se distinguen por su tama\u00f1o (60 y 80 kda). Aunque varios sistemas de segundos mensajeros se ven implicados en la se\u00f1al del tnf alfa, el acoplamiento de la se\u00f1al con los receptores es desconocido. Recientemente se han identificado varias proteinas que se asocian a los receptores de tnf alfa, algunas de ellas pertenecen a la familia de proteinas traf. Estas proteinas de alguna forma pondrian en marcha las diferentes rutas de se\u00f1ales activadas por el tnf alfa, donde estaran implicados procesos de fosforilacion que conducen a la activacion del factor de transcripcion nfk b. Hemos identificado dos proteinas que podrian participar en el mecanismo de<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>La citoquina tnf alfa.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 La citoquina tnf alfa. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Estefania Claudio Vazquez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Oviedo<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1996<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Pedro Sanchez Lazo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Santiago Gascon Mu\u00f1oz <\/li>\n<li>Jorge Moscat Guill\u00e9n (vocal)<\/li>\n<li>Francisco Leyva Cobi\u00e1n (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Estefania Claudio Vazquez El tnf alfa es una citoquina sintetizada por una gran variedad de tipos celulares [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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