{"id":129511,"date":"1996-01-01T00:00:00","date_gmt":"1996-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/los-genes-ras-en-los-adenocarcinomas-nasosinusales\/"},"modified":"1996-01-01T00:00:00","modified_gmt":"1996-01-01T00:00:00","slug":"los-genes-ras-en-los-adenocarcinomas-nasosinusales","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/los-genes-ras-en-los-adenocarcinomas-nasosinusales\/","title":{"rendered":"Los genes ras en los adenocarcinomas nasosinusales."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Paz Perez Vazquez <\/strong><\/h2>\n<p>Se estudio la presencia de activacion de los genes ras en 31 pacientes afectos de adenocarcinomas nasosinusales. Se utilizo la reaccion en cadena de la polimerasa (pcr) para amplificar las secuencias especificas de los genes ras a partir de muestras de tejido congelado o de especimenes incluidos en parafina. La deteccion de las mutaciones se llevo a cabo por medio de hibridacion con sondas oligonucleotidicas especificas de mutacion. Los casos positivos se sometieron a secuenciacion directa.  se encontraron mutaciones en el codon 12 de h-ras en 6 tumores (5 primarios y una recidiva). Todas las mutaciones halladas consistian en una transversion g por t que determina la sustitucion del aminoacido glicina por una valina. Los tumores portadores de dicha mutacion se caracterizaban por presentar un mayor riesgo de desarrollar recidivas (p=0,04) y por una supervivencia acortada (p=0,01). No se encontro ninguna relacion entre la presencia de mutacion y la exposicion previa de los pacientes al polvo de la madera.  en el gen k-ras se detecto una mutacion, en el codon 12, consistente en la transicion g por a. Esta mutacion se mostro asociada con el desarrollo de metastasis ganglionares cervicales.  no se detectaron mutaciones en ningun codon del gen n-ras.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Los genes ras en los adenocarcinomas nasosinusales.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Los genes ras en los adenocarcinomas nasosinusales. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Paz Perez Vazquez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Oviedo<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1996<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Carlos Suarez Nieto<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Pedro Sanchez Lazo <\/li>\n<li>Francisco Esteban Ortega (vocal)<\/li>\n<li>Faustino Jos\u00e9 Nu\u00f1ez Batalla (vocal)<\/li>\n<li>Pedro Quesada Marin (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Paz Perez Vazquez Se estudio la presencia de activacion de los genes ras en 31 pacientes afectos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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