{"id":129611,"date":"1996-01-01T00:00:00","date_gmt":"1996-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/reaparicion-de-acidos-biliares-fetales-durante-la-hepatocarcinogenesis\/"},"modified":"1996-01-01T00:00:00","modified_gmt":"1996-01-01T00:00:00","slug":"reaparicion-de-acidos-biliares-fetales-durante-la-hepatocarcinogenesis","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/reaparicion-de-acidos-biliares-fetales-durante-la-hepatocarcinogenesis\/","title":{"rendered":"Reaparicion de acidos biliares fetales durante la hepatocarcinogenesis."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Nazaret Luengo Nieto <\/strong><\/h2>\n<p>El objetivo de este trabajo fue investigar si la retrodiferenciacion que aparece durante la neoplasia del parenquima hepatico puede puede afectar a las vias de sintesis de acidos biliares (abs). El estudio se realizo sobre 20 sujetos sanos (s), 30 con cirrosis hepatica (c), 12 con cancer secundario de higado (m) y 7 con carcinoma hepatocelular (hcc). Los abs en orina y plasma se analizaron por gc-ms. Los resultados revelaron la presencia de abs minoritarios, tales como los ceto-abs, cuya eliminacion urinaria era similar en s y en c.M. Y hcc. Sin embargo, los abs planos solo aparecian en cantidades traza en la orina de s, eran claramente detectables en c y m, y eran especialmente abundantes en la orina de los pacientes con hcc. Teniendo en cuenta la dificultad de separar las interferencias debidas a las alteraciones hepaticassuperpuestas en estos pacientes, se investigo la aparicion de abs planos experimental. El seguimiento inmunohistoquimico se realizo mediante el uso de un anticuerpo monoclonal especifico contra la gst  .  el analisis de la bilis de estos animales por gc-ms, en etapas del proceso carcinogenico en las que no existian signos de colestasis superpuesta, revelo la existencia de una correlacion positiva entre la magnitud del tejido hepatico que expresa la gst-  y tasa de secrecion biliar de abs planos. Estos resultados sugieren que la retrodiferenciacion ligada a la aparicion de neoplasias del parenquima hepatico conlleva la reaparicion de abs planos tipicos de la vida fetal y ausentes en individuos adultos sanos.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Reaparicion de acidos biliares fetales durante la hepatocarcinogenesis.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Reaparicion de acidos biliares fetales durante la hepatocarcinogenesis. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Nazaret Luengo Nieto <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1996<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Juan Garcia Marin<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Alejandro Esteller  Perez <\/li>\n<li>Eduarda Molina Alcaide (vocal)<\/li>\n<li> Liso Rubio Francisco Javier (vocal)<\/li>\n<li> Del Moral Avila Rosario (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Nazaret Luengo Nieto El objetivo de este trabajo fue investigar si la retrodiferenciacion que aparece durante la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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