{"id":129633,"date":"1996-01-01T00:00:00","date_gmt":"1996-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-de-la-colestasis-materna-sobre-la-maduracion-de-la-funcion-hepatobiliar\/"},"modified":"1996-01-01T00:00:00","modified_gmt":"1996-01-01T00:00:00","slug":"efecto-de-la-colestasis-materna-sobre-la-maduracion-de-la-funcion-hepatobiliar","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/efecto-de-la-colestasis-materna-sobre-la-maduracion-de-la-funcion-hepatobiliar\/","title":{"rendered":"Efecto de la colestasis materna sobre la maduracion de la funcion hepatobiliar."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Morales Martin Ana Isabel <\/strong><\/h2>\n<p>El objeto de este trabajo fue estudiar las repercusiones de la hipefercolanemia materna en la maduracion de la funcion hepatobiliar. Los estudios \u00abin vivo\u00bb, por infusion (i.V.) De taurocolato para simular sobrecargas postprandiales revelaron una menor respuesta coleretica (-41%) y secrecion de acidos biliares (-40%) en ratas de 4 semanas hijas de madres colestaticas. La excrecion de bsp, tambien se encontro disminuida (-45%) en crias de 4 semanas. Los estudios cineticos llevados a cabo en vesiculas de membrana de los diferentes grupos experimentales sugieren la existencia de un fenomeno de \u00abup-regulation\u00bb de los transportadores canaliculares de aciso biliares en hijos de madres colestaticas, el cual podria estar implicado en un intento del sistema hepatobiliar de compensar la deficiencia secretora. El estudio histologico del parenquima hepatico de hijos de ratas colestaticas revela alteraciones caracterizadas por la presencia de estructuras multilamelares en la luz de los canaliculos que podria ser la causa de una colestasis obstructiva intrahepatica multiple. La colestasis maaterna tambien afecto al metabolismo de los acidos biliares, observandose por combinacion de hplc y gc-ms cambios en el patron de conjugacion, asi como un retraso en la desparicion de las especies moleculares tipicamente fetales. En hijos de madres colestaticas tambien se observo una marcada elevacion de acidos y  muricolicos, que podria estar relacionadas con la formacion de las estructuras multilamelares canaliculares. Las alteraciones estructurales, secretoras y metabolicas desparecieron a las 8 semanas de edad.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto de la colestasis materna sobre la maduracion de la funcion hepatobiliar.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto de la colestasis materna sobre la maduracion de la funcion hepatobiliar. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Morales Martin Ana Isabel <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1996<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Juan Garcia Marin<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Alfonso Jes\u00fas Dominguez Gil Hurle <\/li>\n<li>Jos\u00e9 Carlos Fern\u00e1ndez-checa Torres (vocal)<\/li>\n<li>Javier Gonz\u00e1lez Gallego (vocal)<\/li>\n<li>Fernando Perez Barriocanal (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Morales Martin Ana Isabel El objeto de este trabajo fue estudiar las repercusiones de la hipefercolanemia materna [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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