{"id":129656,"date":"1996-01-01T00:00:00","date_gmt":"1996-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/cambios-en-el-metabolismo-de-los-acidos-biliares-durante-la-regeneracion-hepatica-y-la-hepatocarcinogenesis\/"},"modified":"1996-01-01T00:00:00","modified_gmt":"1996-01-01T00:00:00","slug":"cambios-en-el-metabolismo-de-los-acidos-biliares-durante-la-regeneracion-hepatica-y-la-hepatocarcinogenesis","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/cambios-en-el-metabolismo-de-los-acidos-biliares-durante-la-regeneracion-hepatica-y-la-hepatocarcinogenesis\/","title":{"rendered":"Cambios en el metabolismo de los acidos biliares durante la regeneracion hepatica y la hepatocarcinogenesis"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Rodriguez Sainz Garcia Guillermo <\/strong><\/h2>\n<p>Estudios recientes han sugerido que algunos acidos biliares podrian desempe\u00f1ar un papel como moduladores de procesos proliferativos en los tejidos que forman parte de la circulacion enterohepatica. El objetivo de este trabajo fue investigar, en ratas, la magnitud y composicion del \u00abpool\u00bb de acidos biliares durante dos situaciones experimentales que implican proliferacion de los hepatocitos: 1) la regeneracion hepatica compensadora tras hepatectomia parcial, de forma espontanea o tras su sincronizacion mediante la adminsitracion de hidroxiurea y 2) la hepatocarcinogenesis experimental inducida quimicamente por una modificacion del metodo de solt y farber. El tama\u00f1o del \u00abpool\u00bb de acidos biliares se cuantifico por agotamiento del \u00abpool\u00bb de estas moleculas, mediante recogida de muestras de bilis durante 24 horas y determinacion en ellas de la concentracion de acidos biliares totales. La composicion cualitativa \u00abpool\u00bb se analizo por hplc y cromatografia de gases acoplada a espectrometria de masas. Durante la regeneracion hepatica sincronizada el tama\u00f1o del \u00abpool\u00bb de los acidos biliares aumento en los tiempos cortos tras hepatectomia.  sin embargo, en los animales con hepatocarcinogenesis no se encontraron cambios en el tama\u00f1o del \u00abpool\u00bb, aunque la capacidad coleretica de estas moleculas se incremento.  ambos procesos originaron cambios en la composicion cualitativa del \u00abpool\u00bb de acidos biliares. En regeneracion hepatica descendieron fundamentalmente los niveles de acidos biliares trihidroxilados y tauroconjugados. En hepatocarcinogenesis, se redujeron tambien las especies moleculares tauroconjugadas, a excepcion del taurocolato. En cuanto al metabolismo del anillo esteroide, el hecho mas importante es la mayor abundancia relativa de acido colico en la bilis de animales con lesiones hepaticas preneoplasicas y neoplasicas.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Cambios en el metabolismo de los acidos biliares durante la regeneracion hepatica y la hepatocarcinogenesis<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Cambios en el metabolismo de los acidos biliares durante la regeneracion hepatica y la hepatocarcinogenesis <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Rodriguez Sainz Garcia Guillermo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1996<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Juan Garcia Marin<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Rafael Jimenez Fern\u00e1ndez <\/li>\n<li> De La Cadena Tortosa M. Paez (vocal)<\/li>\n<li>Francisco Javier Rodriguez Berrocal (vocal)<\/li>\n<li>Pilar Sanchez Collado (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Rodriguez Sainz Garcia Guillermo Estudios recientes han sugerido que algunos acidos biliares podrian desempe\u00f1ar un papel como [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[8901,9,491,139,156,9386],"tags":[243085,117350,1109,61631,4045,243084],"class_list":["post-129656","post","type-post","status-publish","format-standard","hentry","category-carcinogenesis","category-ciencias-medicas","category-gastroenterologia","category-medicina-interna","category-patologia","category-salamanca","tag-de-la-cadena-tortosa-m-paez","tag-francisco-javier-rodriguez-berrocal","tag-jose-juan-garcia-marin","tag-pilar-sanchez-collado","tag-rafael-jimenez-fernandez","tag-rodriguez-sainz-garcia-guillermo"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/129656","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=129656"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/129656\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=129656"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=129656"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=129656"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}