{"id":129658,"date":"1996-01-01T00:00:00","date_gmt":"1996-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/transporte-hepatobiliar-de-xenobioticos-colefilos-en-el-sindrome-colestatico-inducido-por-ciclosporina-a-en-la-rata-efecto-de-la-s-adenosil-l-metionina\/"},"modified":"1996-01-01T00:00:00","modified_gmt":"1996-01-01T00:00:00","slug":"transporte-hepatobiliar-de-xenobioticos-colefilos-en-el-sindrome-colestatico-inducido-por-ciclosporina-a-en-la-rata-efecto-de-la-s-adenosil-l-metionina","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/transporte-hepatobiliar-de-xenobioticos-colefilos-en-el-sindrome-colestatico-inducido-por-ciclosporina-a-en-la-rata-efecto-de-la-s-adenosil-l-metionina\/","title":{"rendered":"Transporte hepatobiliar de xenobioticos colefilos en el sindrome colestatico inducido por ciclosporina a en la rata. efecto de la s-adenosil-l-metionina"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Ruiz Martin F. Javier <\/strong><\/h2>\n<p>La utilizacion de la cya esta limitada por sus efectos adversos tales como nefrotoxicidad y hepatotoxicidad. En este estudio evaluamos las alteraciones inducidas por el tratamiento con cya, durante dos semanas, sobre el transporte hepatobiliar de los colorantes colefilos, bsp, dbsp e icg. El analisis de los resultados obtenidos tras la inyeccion en dosis unica o infusion continua i.V. De estos revelo que el tratamiento redujo la velocidad de desaparicion plasmatica y la tasa de excrecion biliar y aumento la cantiddad de los colorantes remanente en el higado al finalizar el periodo experimental; ademas, tambien redujo la excrecion biliar de la forma conjugada con glutationde la bsp asi como el contenido hepatico del tripeptido. Estos efectos se atribuyen a una inhibicion inducida por la cya sobre los sistemas de transporte sinusoidal y canalicular y a modificaciones sobre el metabolismo intrahepatico y el transporte intrahepatocitario. Posteriormente, tratamos de paliar estas alteraciones mediante el empleo de same. El contratamiento con cya y same no modifico las alteraciones inducidas por la cya sobre la fase de captacion pero fue capaz de antagonizar total o parcialmente los efectos de la cya sobre la fase limitante, excrecion canalicular, y normalizo los procesos de biotransformacion hepatica de la bsp.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Transporte hepatobiliar de xenobioticos colefilos en el sindrome colestatico inducido por ciclosporina a en la rata. efecto de la s-adenosil-l-metionina<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Transporte hepatobiliar de xenobioticos colefilos en el sindrome colestatico inducido por ciclosporina a en la rata. efecto de la s-adenosil-l-metionina <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Ruiz Martin F. Javier <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1996<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Emilio Fernandez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Javier Gonz\u00e1lez Gallego <\/li>\n<li>Mar\u00eda  Angeles Serrano Garcia (vocal)<\/li>\n<li>Julio Moratinos Areces (vocal)<\/li>\n<li>Jorge Moreno Carretero (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ruiz Martin F. Javier La utilizacion de la cya esta limitada por sus efectos adversos tales como [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,2445,957,9386,401],"tags":[243088,9692,30023,9485,39355,243087],"class_list":["post-129658","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-evaluacion-de-farmacos","category-farmacologia","category-salamanca","category-toxicologia","tag-emilio-fernandez","tag-javier-gonzalez-gallego","tag-jorge-moreno-carretero","tag-julio-moratinos-areces","tag-maria-angeles-serrano-garcia","tag-ruiz-martin-f-javier"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/129658","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=129658"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/129658\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=129658"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=129658"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=129658"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}