{"id":129833,"date":"1996-01-01T00:00:00","date_gmt":"1996-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-del-polimorfismo-del-gen-h-2eb-en-la-proteccion-contra-la-artritis-inducida-por-colageno-implicacion-en-el-papel-de-las-moleculas-drb-en-la-artritis-reumatoide\/"},"modified":"1996-01-01T00:00:00","modified_gmt":"1996-01-01T00:00:00","slug":"efecto-del-polimorfismo-del-gen-h-2eb-en-la-proteccion-contra-la-artritis-inducida-por-colageno-implicacion-en-el-papel-de-las-moleculas-drb-en-la-artritis-reumatoide","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/efecto-del-polimorfismo-del-gen-h-2eb-en-la-proteccion-contra-la-artritis-inducida-por-colageno-implicacion-en-el-papel-de-las-moleculas-drb-en-la-artritis-reumatoide\/","title":{"rendered":"Efecto del polimorfismo del gen h-2eb en la proteccion contra la artritis inducida por colageno: implicacion en el papel de las moleculas drb en la artritis reumatoide."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Gonzalez Gay Mantecon Miguel Angel <\/strong><\/h2>\n<p>La artritis inducida por colageno (cia) es un modelo experimental de artritis reumatoide (ar). La susceptibilidad para la cia murina esta ligada a moleculas h-2a (analogas a las dq humanas) en ratones h-2q y h-2r mientras que en la ar la susceptibilidad depende de las moleculas dr (homologas a las h-2e del raton).  para estudiar la influencia de las moleculas ebeta en la cia se introdujo un transgen ebd en un animal susceptible (b10.Rqb3; h-2q). La presencia del transgen ebd produjo reduccion en la incidencia y severidad de la cia. Despues se observo que el polimorfismo del gen eb influencia la susceptibilidad para la cia en ratornes h-2q. Sin embargo, ninguna molecula ebeta ejercio proteccion frente a la cia en ratones b10.Riii (h-2r). Luego se introdujo un transgen humano dr2dw12-drb1*1502, asociado con bajo riesgo para el desarrollo de ar en un animal h-2q. Este transgen humano produjo proteccion frente a la cia. Estos resultados sugieren que las moleculas h-2e y drb1 pueden desempe\u00f1ar un efecto de proteccion mientras que las h-2a y do pueden ser las responsables de la susceptibilidad para el desarrollo de cia y ar respectivamente.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto del polimorfismo del gen h-2eb en la proteccion contra la artritis inducida por colageno: implicacion en el papel de las moleculas drb en la artritis reumatoide.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto del polimorfismo del gen h-2eb en la proteccion contra la artritis inducida por colageno: implicacion en el papel de las moleculas drb en la artritis reumatoide. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Gonzalez Gay Mantecon Miguel Angel <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Cantabria<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1996<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Vicente Rodriguez Valverde<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Fernando Pons Romero <\/li>\n<li>Antolin Mellado Pollo (vocal)<\/li>\n<li>Jes\u00fas Merino Perez (vocal)<\/li>\n<li>Juan Gomez-reino Carnota (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Gonzalez Gay Mantecon Miguel Angel La artritis inducida por colageno (cia) es un modelo experimental de artritis [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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