{"id":129930,"date":"1996-01-01T00:00:00","date_gmt":"1996-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-en-linfocitos-in-vivo-e-in-vitro-del-intercambio-de-cromatidas-hermanas-y-de-las-alteraciones-cromosomicas-inducidas-por-tratamiento-quimioterapico\/"},"modified":"1996-01-01T00:00:00","modified_gmt":"1996-01-01T00:00:00","slug":"estudio-en-linfocitos-in-vivo-e-in-vitro-del-intercambio-de-cromatidas-hermanas-y-de-las-alteraciones-cromosomicas-inducidas-por-tratamiento-quimioterapico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-en-linfocitos-in-vivo-e-in-vitro-del-intercambio-de-cromatidas-hermanas-y-de-las-alteraciones-cromosomicas-inducidas-por-tratamiento-quimioterapico\/","title":{"rendered":"Estudio en linfocitos in vivo e in vitro del intercambio de cromatidas hermanas y de las alteraciones cromosomicas inducidas por tratamiento quimioterapico."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Delgado Rufino M. Dolores <\/strong><\/h2>\n<p>La deteccion de mutagenos-carcinogenos tanto en el medio ambiente como en el organismo humano, por medio de pruebas a corto plazo \u00abin vivo e in vitro\u00bb ha sido de gran interes en el ultimo decenio.La cuantificacion del numero de intercambios de cromatidas hermanas asi como de las alteraciones cromosomicas, en linfocitos de sangre periferica de individuos expuestos a quimioterapicos, es una prueba que nos permite una evaluacion rapida y directa de la mutagenesis.En nuestro estudio se observa que el numero de intercambios de cromatidas hermanas y alteraciones cromosomicas aumenta significativamente en pacientes tumorales respecto al grupo control: ademas se pudo comprobar que tras el tratamiento quimioterapico la significacion aumenta.Entre los tres farmacos estudiados (mitoxantrona, mitomicina-c y metotrexato), a dosis similares, la mitoxantrona es el que produce el da\u00f1o cromosomico \u00abin vitro\u00bb mas acusado, siendo este da\u00f1o dosis dependiente.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio en linfocitos in vivo e in vitro del intercambio de cromatidas hermanas y de las alteraciones cromosomicas inducidas por tratamiento quimioterapico.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio en linfocitos in vivo e in vitro del intercambio de cromatidas hermanas y de las alteraciones cromosomicas inducidas por tratamiento quimioterapico. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Delgado Rufino M. Dolores <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Sevilla<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1996<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Hugo Galera Davidson<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Alfredo Matilla Vicente <\/li>\n<li> Novales Huerta M. Angeles (vocal)<\/li>\n<li>Alfredo Blanes Berenguel (vocal)<\/li>\n<li> Codes Manuel De Villena Manuel E. (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Delgado Rufino M. Dolores La deteccion de mutagenos-carcinogenos tanto en el medio ambiente como en el organismo [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[212,35,9,2820,52,156,10715],"tags":[7893,7890,66941,243405,7891,63921],"class_list":["post-129930","post","type-post","status-publish","format-standard","hentry","category-biologia-humana","category-ciencias-de-la-vida","category-ciencias-medicas","category-genetica-humana","category-histopatologia","category-patologia","category-sevilla","tag-alfredo-blanes-berenguel","tag-alfredo-matilla-vicente","tag-codes-manuel-de-villena-manuel-e","tag-delgado-rufino-m-dolores","tag-hugo-galera-davidson","tag-novales-huerta-m-angeles"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/129930","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=129930"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/129930\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=129930"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=129930"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=129930"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}