{"id":129993,"date":"1996-01-01T00:00:00","date_gmt":"1996-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/concentraciones-plasmaticas-total-y-libre-de-fenitoina-en-pacientes-epilepticos\/"},"modified":"1996-01-01T00:00:00","modified_gmt":"1996-01-01T00:00:00","slug":"concentraciones-plasmaticas-total-y-libre-de-fenitoina-en-pacientes-epilepticos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/concentraciones-plasmaticas-total-y-libre-de-fenitoina-en-pacientes-epilepticos\/","title":{"rendered":"Concentraciones plasmaticas total y libre de fenitoina en pacientes epilepticos."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Jimenez Plata Manuel Carlos <\/strong><\/h2>\n<p>Para avanzar en el conocimiento de los factores que pueden afectar la union de la fenitoina (dph) a las proteinas plasmaticas y la variabilidad de su fraccion plasmatica libre (fl), se estudiaron 134 muestras procedentes de pacientes epilepticos en tratamiento con dph. La concentracion plasmaticas total y libre (ct y cl) de dph se determinaron por fpia (inmunoensayo de polarizacion fluorescente), y la fraccion libre se separo mediante ultra filtracion a 25 grados centigrados. La ct y cl de dph no dependen de la edad o sexo del paciente, y de forma muy limitada por el regimen terapeutico. La dosis empleada y el sexo no influyen sobre la fl de dph.  la ct no se correlaciona con la fl, por no ser saturable su union. Las concentraciones plasmaticas normales de albumina, proteinas totales, creatinina o bilirrubina, no se relacionan con la fl de dph. La influencia de la edad tiene escasa relevancia clinica pero su efecto no puede ser descartado. La politerapia con acido valproico es el unico factor estudiado que aumenta significativamente la fl de dph y su variabilidad.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Concentraciones plasmaticas total y libre de fenitoina en pacientes epilepticos.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Concentraciones plasmaticas total y libre de fenitoina en pacientes epilepticos. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Jimenez Plata Manuel Carlos <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Sevilla<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1996<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Antonio Dur\u00e1n Quintana<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Sanchez Garcia M. Adela <\/li>\n<li> Saiz Martinez Acitores Jes\u00fas (vocal)<\/li>\n<li> Castillo Ferrando Juan  Ram\u00f3n (vocal)<\/li>\n<li>Pedro Blasco Huelva (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jimenez Plata Manuel Carlos Para avanzar en el conocimiento de los factores que pueden afectar la union [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,2445,957,139,1880,10715],"tags":[8315,243479,26649,1774,110236,243480],"class_list":["post-129993","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-evaluacion-de-farmacos","category-farmacologia","category-medicina-interna","category-neurologia","category-sevilla","tag-castillo-ferrando-juan-ramon","tag-jimenez-plata-manuel-carlos","tag-jose-antonio-duran-quintana","tag-pedro-blasco-huelva","tag-saiz-Martinez-acitores-jesus","tag-sanchez-garcia-m-adela"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/129993","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=129993"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/129993\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=129993"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=129993"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=129993"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}