{"id":130220,"date":"1996-01-01T00:00:00","date_gmt":"1996-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-farmacocinetica-del-busulfan-en-la-rata\/"},"modified":"1996-01-01T00:00:00","modified_gmt":"1996-01-01T00:00:00","slug":"estudio-de-la-farmacocinetica-del-busulfan-en-la-rata","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-de-la-farmacocinetica-del-busulfan-en-la-rata\/","title":{"rendered":"Estudio de la farmacocinetica del busulfan en la rata."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Sara Esteve Poblador <\/strong><\/h2>\n<p>Para el desarrollo de esta memoria, ha sido necesario el uso de diversas tecnicas quirurgicas, las cuales permiten la administracion de los preparados intravenosos y el muestreo sanguineo arterial y venoso en animales conscientes, asi como la obtencion de leche. Ademas, se ha utilizado un metodo analitico basado en la cromatografia liquido-liquido de alta eficacia con deteccion fluorimetrica.  en primer lugar, se estudio la farmacocinetica iv del busulfan en los animales de experimentacion a diferentes dosis (5,0,5 y 0,152 mg), concluyendose que el busulfan, a dosis elevadas, presenta un comportamiento cinetico no lineal en la rata, y que el empleo de un modelo de disposicion bicompartimental permite una adecuada descripcion de la farmacocinetica del antineoplasico.  en segundo lugar, se estudio la influencia de tres anticonvulsivantes (clonazepam, fenitoina y fenobarbital) en la farmacocinetica del busulfan. Los resultados de este estudio han permitido concluir que, cuando se administran anticonvulsivantes con efectos inductores enzimaticos (fenitoina y fenobarbital) aumenta el aclaramiento del antineoplasico. Sin embargo, este efecto no se observa en el caso de la administracion conjunta de clonazepam y busulfan.  finalmente, se estudio la distribucion del busulfan a diferentes tejidos y organos de la rata, asi como la distribucion a la leche. De los resultados obtenidos, se deduce que el antineoplasico se distribuye a todos los tejidos y organos ensayados: musculo, grasa, testiculo, intestino, estomago, ri\u00f1on, higado, pulmon, corazon, piel y medula osea, asi como al liquido cefalorraquideo.  ademas, el busulfan tambien accede a la leche, alcanzandose concentraciones ligeramente inferiores a las plasmaticas.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la farmacocinetica del busulfan en la rata.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la farmacocinetica del busulfan en la rata. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Sara Esteve Poblador <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1996<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Peris Ribera Jos\u00e9 E.<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Ram\u00f3n Mart\u00ednez Pacheco <\/li>\n<li>Antonio Rabasco Alvarez (vocal)<\/li>\n<li>Jos\u00e9 Martinez Calatayud (vocal)<\/li>\n<li> Candenas De Lujan Luz (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Sara Esteve Poblador Para el desarrollo de esta memoria, ha sido necesario el uso de diversas tecnicas [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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