{"id":130316,"date":"1996-01-01T00:00:00","date_gmt":"1996-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/profilaxis-en-cirugia-biliar-con-cefalosporinas-de-vida-media-corta-y-larga-en-dosis-unica-estudio-farmacocinetico-y-clinico\/"},"modified":"1996-01-01T00:00:00","modified_gmt":"1996-01-01T00:00:00","slug":"profilaxis-en-cirugia-biliar-con-cefalosporinas-de-vida-media-corta-y-larga-en-dosis-unica-estudio-farmacocinetico-y-clinico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/profilaxis-en-cirugia-biliar-con-cefalosporinas-de-vida-media-corta-y-larga-en-dosis-unica-estudio-farmacocinetico-y-clinico\/","title":{"rendered":"Profilaxis en cirugia biliar con cefalosporinas de vida media corta y larga en dosis unica. estudio farmacocinetico y clinico."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Javier Martin Delgado <\/strong><\/h2>\n<p>Con la profilaxis antibiotica en cirugia se persigue conseguir niveles sericos y tisulares por encima de las cmi de los posibles germenes contaminantes. Hemos utilizado dos cefalosporinas de 2 generacion (con baja y alta afinidad a las proteinas plasmaticas respectivamente), que se administraron en la induccion anestesica a 2 grupos de enfermos sometidos a colecistectomia abierta, tomando muestras de sangre, bilis y tejidos (pared de vesicula, musculo y grasa) para el estudio farmacocinetico, valorando las distintas muestras mediante cromatografia liquida. Se realizo estimacion de parametros farmacocineticos individuales y poblacionales. Las concentraciones plasmaticas de los dos antibioticos fueron superiores a las cmi de los germenes habituales, salvo en el caso del streptococcus fecalis para la cefuroxima. Los valores obtenidos en la bilis de coledoco son notablemente superiores a los de bilis de vesicula. En los tejidos, destaca el nivel alcanzado en la pared de vesicula biliar. 51 pacientes de 123 investigados, presentaron bacteriobilia, con independencia de que la profilaxis se realizara en la induccion (23) o en otro momento (28).  entre los 80 enfermos (43.47%) que recibieron profilaxis en la induccion hubo 2 infecciones (2,5%) y 12 (11,5%) entre los 104 (56,52%) que no recibieron profilaxis en la induccion, existiendo diferencias estadisticamente significativas entre ambos grupos.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Profilaxis en cirugia biliar con cefalosporinas de vida media corta y larga en dosis unica. estudio farmacocinetico y clinico.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Profilaxis en cirugia biliar con cefalosporinas de vida media corta y larga en dosis unica. estudio farmacocinetico y clinico. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Javier Martin Delgado <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1996<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Ponce Marco Jos\u00e9 Luis<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan  (secretario) Ruiz Del Castillo <\/li>\n<li>Victor Jimenez Torres (vocal)<\/li>\n<li>Javier Deus Fombellida (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Javier Martin Delgado Con la profilaxis antibiotica en cirugia se persigue conseguir niveles sericos y tisulares por [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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