{"id":130328,"date":"1996-01-01T00:00:00","date_gmt":"1996-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-sensibilidad-periferica-a-la-insulina-en-la-hiperlipemia-familiar-combinada-aplicacion-del-modelo-minimo-del-metabolismo-de-la-glucosa\/"},"modified":"1996-01-01T00:00:00","modified_gmt":"1996-01-01T00:00:00","slug":"estudio-de-la-sensibilidad-periferica-a-la-insulina-en-la-hiperlipemia-familiar-combinada-aplicacion-del-modelo-minimo-del-metabolismo-de-la-glucosa","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-de-la-sensibilidad-periferica-a-la-insulina-en-la-hiperlipemia-familiar-combinada-aplicacion-del-modelo-minimo-del-metabolismo-de-la-glucosa\/","title":{"rendered":"Estudio de la sensibilidad periferica a la insulina en la hiperlipemia familiar combinada. aplicacion del modelo minimo del metabolismo de la glucosa."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Agustin Angel Merchante Alfaro <\/strong><\/h2>\n<p>Introduccion: la hiperlipemia familiar combinada (hfc) es la hiperlipemia primaria mas frecuente entre los supervivientes a un infarto agudo de miocardio precoz. Se caracteriza por la presencia por varios fenotipos lipoproteicos (iia, iib y iv) entre los familiares de primer grado y por la asociacion a multiples trastornos del metabolismo lipidico y de los hidratos de carbono. La resistencia a la insulina podria ser uno de los factores implicados en la patogenia de esta enfermedad.  objetivos: estudiar la sensibilidad periferica a la insulina en la hfc utilizando la tecnica del modelo minimo aproximado del metabolismo de la glucosa (mmamg), modificando el protocolo standard (administracion de 300 mg\/kg de glucosa i.V. Y extraccion de multiples muestras para la determinacion de glucosa e insulina) con la administracion de 0.03 u. De insulina rapida i.V. A los 20 minutos de la administracion de glucosa.  metodos: hemos estudiado 19 varones diagnosticados de hfc normotensos, no diabeticos, y a 19 controles sanos apareados en edad, sexo, imc e icc, seleccionados durante 18 meses. Realizamos un estudio del metabolismo lipidico, una sobrecarga oral de glucosa, y el calculo del indice de sensibilidad periferica a la insulina (indice si) utilizando la tecnica del mmamg modificado con insulina.  resultados y conclusiones: hemos hallado un descenso del indice si en el grupo de pacientes con hfc frente al grupo control (1.6 +- 0.9 frente a 2.8 +- 1.2 x 10-4 (min-1\/micro u\/ml). Asi mismo hemos encontrado en el grupo de pacientes otras de las caracteristicas propias del sindrome de resistencia a la insulina (hiperinsulinismo, aumento de los acidos grasos libres, descenso de las hdl, elevada preValencia de trastornos de la tolerancia a la glucosa). El descenso del indice si se presenta tanto en pacientes con hfc obesos (imc 27kg\/m2), como en no obesos, afectando fundamentalmente a los pacientes con fenotipo lipoproteico iib y iv. El indice s<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la sensibilidad periferica a la insulina en la hiperlipemia familiar combinada. aplicacion del modelo minimo del metabolismo de la glucosa.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la sensibilidad periferica a la insulina en la hiperlipemia familiar combinada. aplicacion del modelo minimo del metabolismo de la glucosa. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Agustin Angel Merchante Alfaro <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1996<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Rafael Carmena Rodriguez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Manuel Serano Rios <\/li>\n<li>Juan  F Ascaso Gimilio (vocal)<\/li>\n<li>Celestino Rey-joly Barroso (vocal)<\/li>\n<li>Guillermo Saez Tormo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Agustin Angel Merchante Alfaro Introduccion: la hiperlipemia familiar combinada (hfc) es la hiperlipemia primaria mas frecuente entre [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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