{"id":13034,"date":"2018-03-09T08:59:10","date_gmt":"2018-03-09T08:59:10","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/modulacion-de-la-neurotransmision-noradrenergica-por-el-estres-efecto-del-tratamiento-cronico-con-desipramina\/"},"modified":"2018-03-09T08:59:10","modified_gmt":"2018-03-09T08:59:10","slug":"modulacion-de-la-neurotransmision-noradrenergica-por-el-estres-efecto-del-tratamiento-cronico-con-desipramina","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/modulacion-de-la-neurotransmision-noradrenergica-por-el-estres-efecto-del-tratamiento-cronico-con-desipramina\/","title":{"rendered":"Modulacion de la neurotransmision noradrenergica por el estr\u00e9s. efecto del tratamiento cronico con desipramina."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Beatriz Corcostegui Santiago <\/strong><\/h2>\n<p>A lo largo de la vida es frecuente experimentar situaciones de estr\u00e9s. dado que, desgraciadamente, una inadecuada respuesta del organismo al estr\u00e9s se ha relacionado con la aparici\u00f3n y\/o el mantenimiento de trastornos depresivos, numerosos modelos de la depresi\u00f3n humana se han basado en la exposici\u00f3n del animal de experimentaci\u00f3n a distintos estimulos estresantes. Por otra parte, la depresi\u00f3n humana se ha relacionado con alteraciones en la neurotransmisi\u00f3n noradren\u00e9rgica, as\u00ed como con alteraciones en la actividad del eje hipot\u00e1lamo-hipofisario-adrenal (hha). Uno de los modelos animales de la depresi\u00f3n humana que posee mayor validez es el estr\u00e9s cronico variable (ecv), ya que promueve un comportamiento en el animal que remeda parte de la sintomatolog\u00eda descrita en la depresion humana y que es revertido por el tratamiento cr\u00f3nico con antidepresivos.  el objetivo de este trabajo fue contrastar el compartimento animal y la modulaci\u00f3n de la neurotransmisi\u00f3n noradren\u00e9rgica tras la exposici\u00f3n a un estr\u00e9s cronico repetido (ecr) y a un ecv, asi como evaluar dicha neurotransmisi\u00f3n tras el tratamiento cr\u00f3nico con el antidepresivo desipramina(dmi). Adem\u00e1s se valor\u00f3 la implicaci\u00f3n de los distinos subtipos de adrenoceptores a2(ar-a2) en la regulacion de la sintesis de na y su susceptibilidad a ser modulados por el tratamiento cronico con dmi.Por ultimo, se valoro el efecto del tratamiento cronico con dmi sobre el comportamiento animal y la neurotransmisi\u00f3n noradren\u00e9rgica en un modelo animal de la depresi\u00f3n humana como es el ecv.  tanto durante un estr\u00e9s de distinta naturaleza como un vez finalizado el ecr, el contenido de noradrenalina (na) no se modifica, aun encontrandose reducida su sintesis de na, recuperandose, dicha sensibilidad, durante el estr\u00e9s. Sin embargo, el ecr no modula la sensibilidad de los ar-a2 que regulan, a nivel periferico, la contracci\u00f3n del conducto deferente. Por otro  lado, el ecr incrementa el tie<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Modulacion de la neurotransmision noradrenergica por el estr\u00e9s. efecto del tratamiento cronico con desipramina.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Modulacion de la neurotransmision noradrenergica por el estr\u00e9s. efecto del tratamiento cronico con desipramina. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Beatriz Corcostegui Santiago <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 28\/09\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Pilar Areso Goiricelaya<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Luisa Ugedo urruela <\/li>\n<li>\u00e1ngel Pazos carro (vocal)<\/li>\n<li>Antonio Quintana loyola (vocal)<\/li>\n<li>Manuel Baeyens jose (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Beatriz Corcostegui Santiago A lo largo de la vida es frecuente experimentar situaciones de estr\u00e9s. dado que, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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