{"id":130407,"date":"1996-01-01T00:00:00","date_gmt":"1996-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-comparativo-de-la-eficacia-antiinflamatoria-y-antioxidante-de-diferentes-farmacos-sobre-un-modelo-de-uveitis-experimental-mediada-por-endotoxina-intravitrea\/"},"modified":"1996-01-01T00:00:00","modified_gmt":"1996-01-01T00:00:00","slug":"estudio-comparativo-de-la-eficacia-antiinflamatoria-y-antioxidante-de-diferentes-farmacos-sobre-un-modelo-de-uveitis-experimental-mediada-por-endotoxina-intravitrea","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-comparativo-de-la-eficacia-antiinflamatoria-y-antioxidante-de-diferentes-farmacos-sobre-un-modelo-de-uveitis-experimental-mediada-por-endotoxina-intravitrea\/","title":{"rendered":"Estudio comparativo de la eficacia antiinflamatoria y antioxidante de diferentes farmacos sobre un modelo de uveitis experimental mediada por endotoxina intravitrea."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Antonio Rodriguez Galietero <\/strong><\/h2>\n<p>Se realizaron ensayos comparativos sobre la potencia antiinflamatoria y antioxidante de esteroides (prednisolona, fluorometolona, beta-metasona), aines (ketorolaco, flurbiprofeno), antioxidantes (orgoteina, l-name, ebselen) y clorpromazina sobre un modelo experimental de uveitis inducida por endotoxina (uie) intravitrea en el conejo albino raza new zealand. Los parametros analizados fueron: contaje de la celularidad inflamatoria en acuoso, contaje de proteinas en acuoso, determinacion de malonil dialdehido (mda) en acuoso, estudios clinicos y anatomopatologicos. Se obtuvieron las siguientes conclusiones: 1) los aines (ketorolaco y flurbiprofeno) y la orgoteina no demuestran efectividad en el tratamiento de la uie; 2) los farmacos experimentales (l-name y ebselen) y la clorpromazina, son clinica, analitica e histopatologicamente tan eficaces en poder antiinflamatorio como los corticoides de mayor potencia (beta-metasona y prednisolona), mostrandose superiores a los esteroides de potencia intermedia (fluorometolona) en el tratamiento de la uie;3) el antioxidante sintetico ebselen es el unico farmaco que manifiesta una clara eficacia y potencia en la reduccion de la concentracion de malonil dialdehido (mda) en humor acuoso sobre el modelo de uie;4) la orgoteina, farmaco antiinflamatorio y antioxidante empleado en el tratamiento de inflamaciones osteoarticulares, es ineficaz en el tratamiento de la uie;5) el farmaco experimental l-name demuestra un marcado efecto protector sobre la adhesion de leucocitos polimorfonucleares al endotelio de la cornea;6) el flurbiprofeno muestra una gran eficacia en el tratamiento de la miosis inducida en el modelo de uie;7) en el modelo de uie puede deducirse la existencia de un mecanismo patogenico multifactorial en el tienen un protagonismo:a) las rutas clasicas de metabolizacion del acido araquidonico (lipooxigenasa y ciclooxigenasa), demostradas por la accion manifiesta de aines y corticoides;b) las<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio comparativo de la eficacia antiinflamatoria y antioxidante de diferentes farmacos sobre un modelo de uveitis experimental mediada por endotoxina intravitrea.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio comparativo de la eficacia antiinflamatoria y antioxidante de diferentes farmacos sobre un modelo de uveitis experimental mediada por endotoxina intravitrea. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Antonio Rodriguez Galietero <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1996<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Manuel D\u00edaz Llopis<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Antonia Fons Moreno <\/li>\n<li>Jos\u00e9 Javier Araiz Iribarren (vocal)<\/li>\n<li>Edmundo Uson Gonzalez (vocal)<\/li>\n<li>Desamparados Navea Tejerina (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Antonio Rodriguez Galietero Se realizaron ensayos comparativos sobre la potencia antiinflamatoria y antioxidante de esteroides (prednisolona, fluorometolona, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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