{"id":130494,"date":"1996-01-01T00:00:00","date_gmt":"1996-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/influencia-de-diferentes-pautas-de-administracion-de-ciclosporina-a-en-el-desarrollo-de-un-modelo-de-melanoma-uveal\/"},"modified":"1996-01-01T00:00:00","modified_gmt":"1996-01-01T00:00:00","slug":"influencia-de-diferentes-pautas-de-administracion-de-ciclosporina-a-en-el-desarrollo-de-un-modelo-de-melanoma-uveal","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/influencia-de-diferentes-pautas-de-administracion-de-ciclosporina-a-en-el-desarrollo-de-un-modelo-de-melanoma-uveal\/","title":{"rendered":"Influencia de diferentes pautas de administracion de ciclosporina a en el desarrollo de un modelo de melanoma uveal."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Gonzalo Blanco Mateos <\/strong><\/h2>\n<p>Introduccion: el objetivo de este estudio es comparar diferentes dosis de ciclosporina a (csa) en un modelo de melanoma de uvea para probar tratamientos locales y sistemicos.Metodos. Se implanto en coroides la linea celular mkt-br en cuatro grupos de 20 conejos albinos, que recibieron 20 mg\/k\/dia, 15 mg\/kg\/dia y pauta variable de csa (grupos 3,2 y 1) y ningun tratamiento inmunosupresor (grupo control). La evolucion oftalmoscopica, analitica (bun, alt, creatinina), de niveles de csa en sangre, de peso y de efectos secundarios se realizo semanalmente por 2 meses. Se realizaron autopsias de los animales y el globo ocular, pulmon e higado fue estudiado histopatologicamente.  resultados. La mejor supervivencia se produjo en el grupo 2 (mediana 6 semanas). Los niveles de bun y creatinina fueron mayores en el grupo 3. Se desarrollaron tumores oftalmoscopicamente detectables en el 50%, 65% y 70% de los animales en el grupo 1, 2 y 3 respectivamente, y en la evaluacion histopatologica en 70%, 90% y 100% de casos en los mismos grupos. Aparecieron diferencias en los niveles medios de csa en sangre entre los animales que desarrollaron tumor y los que no lo hicieron. Aparecieron metastasis pulmonares en 20%, 40% y 20% de casos en los grupos 1, 2 y 3 respectivamente. Conclusiones. El modelo reproduce la enfermedad local y sistemica con alta eficacia y los niveles sanguineos de csa determinan el desarrollo del tumor y la sumpervivencia de los animales.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Influencia de diferentes pautas de administracion de ciclosporina a en el desarrollo de un modelo de melanoma uveal.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Influencia de diferentes pautas de administracion de ciclosporina a en el desarrollo de un modelo de melanoma uveal. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Gonzalo Blanco Mateos <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Valladolid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1996<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Saornil Alvarez M. Antonia<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Carlos Pastor Jimeno <\/li>\n<li> Calvo Manuel Felipe Angel (vocal)<\/li>\n<li>John Hungerford (vocal)<\/li>\n<li>Jos\u00e9 Luis Sarasa Corral (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Gonzalo Blanco Mateos Introduccion: el objetivo de este estudio es comparar diferentes dosis de ciclosporina a (csa) [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[155,9,988,1027,156,12451],"tags":[61588,124690,244073,12508,29918,62684],"class_list":["post-130494","post","type-post","status-publish","format-standard","hentry","category-ciencias-clinicas","category-ciencias-medicas","category-oftalmologia","category-oncologia","category-patologia","category-valladolid","tag-calvo-manuel-felipe-angel","tag-gonzalo-blanco-mateos","tag-john-hungerford","tag-jose-carlos-pastor-jimeno","tag-jose-luis-sarasa-corral","tag-saornil-alvarez-m-antonia"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/130494","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=130494"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/130494\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=130494"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=130494"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=130494"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}