{"id":130507,"date":"1996-01-01T00:00:00","date_gmt":"1996-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-farmacocinetico-de-la-vancomicina-intravitrea-en-ojos-con-endoftalmitis\/"},"modified":"1996-01-01T00:00:00","modified_gmt":"1996-01-01T00:00:00","slug":"estudio-farmacocinetico-de-la-vancomicina-intravitrea-en-ojos-con-endoftalmitis","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-farmacocinetico-de-la-vancomicina-intravitrea-en-ojos-con-endoftalmitis\/","title":{"rendered":"Estudio farmacocinetico de la vancomicina intravitrea en ojos con endoftalmitis."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Coco Martin Rosa M. <\/strong><\/h2>\n<p>Introduccion: las endoftalmitis son graves procesos inflamatorios de las estructuras intraoculares, que suelen presentarse como complicacion de la cirugia o de los traumatismos penetrantes. El tratamiento de esta patolog\u00eda continua siendo un reto para la oftalmolog\u00eda, ya que se siguen produciendo fracasos terapeuticos a pesar de la utilizacion de antibioticos cada vez mas eficaces por via intravitrea. La mayor parte de los autores piensan que ello es debido a la utilizacion de pautas empiricas de tratamiento. Asi, se propuso como objetivo fundamental de este trabajo, conocer los parametros farmacocineticos de la vancomicina intravitrea, con el fin de establecer un tratamiento mas racional.  material y metodos: se utilizaron un total de 188 conejos pigmentados, en los que se estudio la cinetica de eliminacion de la dosis de 1 mg de vancomicina en ojos normales e infectados. Luego se estudio la cinetica de 0,5 mg en dosis unica y en multidosis. Finalmente se calculo un regimen teorico de multidosis cuya eficacia se comprobo desde el punto de vista clinico y microbiologico.  resultados: se comprobo que los parametros farmacocineticos y la ruta de eliminacion del medicamento variaban considerablemente al tratarse de ojos infectados, disminuyendo la vida media de la dosis de 1 mg desde 62 a 13 horas, y utilizando la via retiniana en lugar de la via anterior como ruta primaria de salida. En cuanto a la dosis de 0,5 mg en ojos infectados, apenas variaba con respecto a la de 1 mg. La cinetica de la multidosis mostro que no se producia acumulacion del medicamento y que se alcanzaba el estado estacionario desde el primer momento. El nuevo regimen terapeutico demostro ser eficaz en el control de la infeccion y la inflamacion. Las concentraciones vitreas con 1 mg podrian ser toxicas.  conclusiones: para un regimen de dosis multiples, quizas seria adecuado utilizar la dosis de 0,5 mg y un intervalo de dosificacion de 36 horas. La cinetica<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio farmacocinetico de la vancomicina intravitrea en ojos con endoftalmitis.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio farmacocinetico de la vancomicina intravitrea en ojos con endoftalmitis. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Coco Martin Rosa M. <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Valladolid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1996<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Lopez Galvez M. Isabel<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Carlos Pastor Jimeno <\/li>\n<li>Mar\u00eda Del Carmen Dios Vi\u00e9itez (vocal)<\/li>\n<li>Miguel Fernandez Refojo (vocal)<\/li>\n<li>Sergi Erill Saez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Coco Martin Rosa M. Introduccion: las endoftalmitis son graves procesos inflamatorios de las estructuras intraoculares, que suelen [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[212,35,9,189,484,7263,12451],"tags":[244087,12508,45734,51408,21110,34358],"class_list":["post-130507","post","type-post","status-publish","format-standard","hentry","category-biologia-humana","category-ciencias-de-la-vida","category-ciencias-medicas","category-farmacodinamia","category-mecanismos-de-accion-de-la-quimioterapia","category-organos-sensoriales","category-valladolid","tag-coco-martin-rosa-m","tag-jose-carlos-pastor-jimeno","tag-lopez-galvez-m-isabel","tag-maria-del-carmen-dios-vieitez","tag-miguel-fernandez-refojo","tag-sergi-erill-saez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/130507","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=130507"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/130507\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=130507"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=130507"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=130507"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}