{"id":130909,"date":"1996-01-01T00:00:00","date_gmt":"1996-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/factores-de-crecimiento-y-eicosanoides-estudio-experimental-in-vitro-de-los-mecanismos-de-reparacion-de-la-mucosa-esofagica\/"},"modified":"1996-01-01T00:00:00","modified_gmt":"1996-01-01T00:00:00","slug":"factores-de-crecimiento-y-eicosanoides-estudio-experimental-in-vitro-de-los-mecanismos-de-reparacion-de-la-mucosa-esofagica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/factores-de-crecimiento-y-eicosanoides-estudio-experimental-in-vitro-de-los-mecanismos-de-reparacion-de-la-mucosa-esofagica\/","title":{"rendered":"Factores de crecimiento y eicosanoides. estudio experimental in vitro de los mecanismos de reparacion de la mucosa esofagica."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Pilar Jimenez Molinos <\/strong><\/h2>\n<p>Los factores de crecimiento y las prostaglandinas juegan un importante papel en la reparacion y proteccion de la mucosa gastrointestinal; sin embargo, su funcion en la mucosa esofagica es menos conocida. Objetivos: determinar las vias metabolicas y\/o metabolitos fundamentales del acido araquidonico (aa) por las celulas epiteliales de la mucosa esofagica; asi como evaluar la funcion de estos metabolitos y de los factores de crecimiento (egf, tfg-alfa, tgf-beta, pdgf-bb, igf-i) en los mecanismos de reparacion celular esofagica expresados en terminos de proliferacion y restitucion. Metodos: se realizo un cultivo primario de celulas de la mucosa esofagica de conejo blanco de nueva zelanda, despues de separar la mucosa de las capas adyacentes, raspado de la submucosa, y posterior digestion en un ringer krebs con colagenasa y tripsina durante 1 hora. Las celulas se cultivaron en un medio de cultivo especifico a 37 grados centigrados, 5% co2, hasta un estado confluente o subconfluente. La determinacion de eicosanoides se realizo, previa adicion de 14c-aa (10  m), por hplc, ria y cromatografia en capa fina. Los estudios de proliferacion celular se realizaron en cultivos subconfluentes determinando la incorporacion de 3h-timidina (1 ci\/ml) en el adn celular. La restitucion se evaluo en celulas confluentes en las que se efectuo una lesion circular, mediante una punta rotante de material plastico de polivinilo, y se cuantifico el area libre de celulas (mm2); o una lesion longitudinal en la que se evaluo la migracion celular a partir del margen de la lesion ( m) a diferentes tiempos (6 horas, 18h y 24h). Los estudios de proliferacion y restitucion se realizaron en celulas desprovistas de suero durante 24 horas y 72 horas.  los resultados de este trabajo indican que las celulas epiteliales de la mucosa esofagica presentan una cinetica de proliferacion diferente a la descrita en otras lineas celulares del epitelio del tracto digestivo, y que ta<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Factores de crecimiento y eicosanoides. estudio experimental in vitro de los mecanismos de reparacion de la mucosa esofagica.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Factores de crecimiento y eicosanoides. estudio experimental in vitro de los mecanismos de reparacion de la mucosa esofagica. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Pilar Jimenez Molinos <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Zaragoza<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1996<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Francisco Esteva D\u00edaz<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Ricardo Sainz Samitier <\/li>\n<li>J. Oriol Bulbena Moreu (vocal)<\/li>\n<li>Gertrudis Juste Rullo (vocal)<\/li>\n<li>Vicente Garrigues Gil (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Pilar Jimenez Molinos Los factores de crecimiento y las prostaglandinas juegan un importante papel en la reparacion [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,491,139,13610],"tags":[91219,86424,29517,244564,18028,78618],"class_list":["post-130909","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-gastroenterologia","category-medicina-interna","category-zaragoza","tag-francisco-esteva-diaz","tag-gertrudis-juste-rullo","tag-j-oriol-bulbena-moreu","tag-pilar-jimenez-molinos","tag-ricardo-sainz-samitier","tag-vicente-garrigues-gil"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/130909","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=130909"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/130909\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=130909"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=130909"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=130909"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}