{"id":130910,"date":"1996-01-01T00:00:00","date_gmt":"1996-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/sintesis-asimetrica-de-ciclopropilaminoacidos-de-interes-biologico\/"},"modified":"1996-01-01T00:00:00","modified_gmt":"1996-01-01T00:00:00","slug":"sintesis-asimetrica-de-ciclopropilaminoacidos-de-interes-biologico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/sintesis-asimetrica-de-ciclopropilaminoacidos-de-interes-biologico\/","title":{"rendered":"Sintesis asimetrica de ciclopropilaminoacidos de interes biologico."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Jimenez Sanz Ana Isabel <\/strong><\/h2>\n<p>Teniendo en cuenta, por una parte, la gran importancia de los aminoacidos ciclopropanicos y, por otra, la falta de metodos generales y selectivos que proporcionen estos compuestos, se planteo la busqueda de nuevas rutas sinteticas que permitiesen subsanar esta carencia.Asi, una vez obtenido el miembro mas sencillo de la serie, el acido 1-aminociclopropancarboxilico, y algunos de sus derivados sustituidos en forma racemica, se abordo el problema desde el punto de vista asimetrico. Con este fin, se llevo a cabo el dise\u00f1o de un nuevo precursor de aminoacidos convenientemente derivatizado, para que mostrase buena reactividad, y conteniendo en su estructura un auxiliar quiral con cierto grado de rigidez conformacional, de modo que fuese capaz de inducir asimetria.  estas caracteristicas condujeron a muy buenos resultados en la reaccion de ciclopropanacion, tanto con diazometano como con iluros de azufre. Ademas, el analisis exhaustivo de los factores que intervienen en el proceso permitio determinar las condiciones optimas para la obtencion preferente de cada diastereoisomero.  finalmente, se llevo a cabo la transformacion de uno de los productos en diferentes ciclopropilaminoacidos enantiomericamente puros, quedando demostrado el enorme valor sintetico de estos sintones quirales como intermedios en la sintesis asimetrica de los compuestos deseados.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Sintesis asimetrica de ciclopropilaminoacidos de interes biologico.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Sintesis asimetrica de ciclopropilaminoacidos de interes biologico. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Jimenez Sanz Ana Isabel <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Zaragoza<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1996<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Carlos Cativiela Mar\u00edn<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Ernest Giralt Lledo <\/li>\n<li>Sergio Castillon Miranda (vocal)<\/li>\n<li>Manuel Bernab\u00e9 Pajares (vocal)<\/li>\n<li> Garcia Laureiro Jos\u00e9 Ignacio (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jimenez Sanz Ana Isabel Teniendo en cuenta, por una parte, la gran importancia de los aminoacidos ciclopropanicos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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