{"id":130943,"date":"1996-01-01T00:00:00","date_gmt":"1996-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/papel-de-los-radicales-libres-en-la-esofagitis-mediada-por-acido-y-pepsina-estudio-experimental\/"},"modified":"1996-01-01T00:00:00","modified_gmt":"1996-01-01T00:00:00","slug":"papel-de-los-radicales-libres-en-la-esofagitis-mediada-por-acido-y-pepsina-estudio-experimental","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/papel-de-los-radicales-libres-en-la-esofagitis-mediada-por-acido-y-pepsina-estudio-experimental\/","title":{"rendered":"Papel de los radicales libres en la esofagitis mediada por acido y pepsina: estudio experimental."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Naya Galvez M. Jose <\/strong><\/h2>\n<p>La esofagitis por reflujo es un proceso patologico desencadenado por la presencia de acido y pepsina en la mucosa esofagica. Los mecanismos de lesion intimos a nivel de la mucosa son poco conocidos. En este sentido, si bien esta adecuadamente fundamentada la implicacion de los radicales libres en los procesos de lesion gastrointestinal, se desconoce si estos pueden mediar la lesion esofagica inducida por acido y pepsina.  objetivos: evaluar si los radicales libres estan implicados en la lesion esofagica asociada a la agresion acido-peptica y abrir futuras alternativas terapeuticas.  material y metodos: estudios in vivo: en conejos blancos de nueva zelanda se induce esofagitis aguda tras exposicion mucosa a una solucion recirculante de pepsina acidificada. Durante la exposicion se administro i.V.  placebo, substancias \u00abbarredoras\u00bb de radicales libres (dimetilsulfoxido, catalasa, superoxido dismutasa) y ketotifeno, inhibidor de la quimiotaxis leucocitaria.  como parametros de da\u00f1o mucoso se evaluaron los indices macro y microscopico de lesion, los flujos ionicos de h+ y k+ y el sangrado mucoso. Estudios in vitro : se aislaron celulas de mucosa esofagica mediante doble digestion enzimatica, disrupcion mecanica, centrifugacion y filtrado, que posteriormente fueron analizadas por citometria de flujo y microscopia. Se determino anion superoxido y peroxido de hidrogeno intracelular, asi como la viabilidad en celulas aisladas de mucosa esofagica sana y tras exposicion acido-peptica. Tambien se determinaron celulas cd11b+ (macrofagos, neutrofilos y monocitos) tras la agresion y su produccion de anion superoxido.  resultados: de las substancias utilizadas, la superoxido dismutasa, \u00abbarredor\u00bb especifico de anion superoxido, y el ketotifeno, redujeron significativamente todos los parametros de lesion mucosa estudiados. Tras la agresion acido-peptica, las celulas aisladas incrementaron la produccion de anion superoxido y se observo un au<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Papel de los radicales libres en la esofagitis mediada por acido y pepsina: estudio experimental.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Papel de los radicales libres en la esofagitis mediada por acido y pepsina: estudio experimental. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Naya Galvez M. Jose <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Zaragoza<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1996<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Alda Torrubia Jos\u00e9 Octavio<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Ricardo Sainz Samitier <\/li>\n<li>Josep Mar\u00eda Pique Badia (vocal)<\/li>\n<li> Escanero Marcen Jes\u00fas F. (vocal)<\/li>\n<li>Fermin Mearin Manrique (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Naya Galvez M. Jose La esofagitis por reflujo es un proceso patologico desencadenado por la presencia de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,491,139,13610],"tags":[28774,13403,134817,29285,244608,18028],"class_list":["post-130943","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-gastroenterologia","category-medicina-interna","category-zaragoza","tag-alda-torrubia-jose-octavio","tag-escanero-marcen-jesus-f","tag-fermin-mearin-manrique","tag-josep-maria-pique-badia","tag-naya-galvez-m-jose","tag-ricardo-sainz-samitier"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/130943","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=130943"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/130943\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=130943"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=130943"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=130943"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}