{"id":131023,"date":"1996-01-01T00:00:00","date_gmt":"1996-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/expresion-del-oncogen-her2-neu-p53-y-otros-factores-clinico-patologicos-en-el-cancer-de-mama-con-afectacion-ganglionar-axilar\/"},"modified":"1996-01-01T00:00:00","modified_gmt":"1996-01-01T00:00:00","slug":"expresion-del-oncogen-her2-neu-p53-y-otros-factores-clinico-patologicos-en-el-cancer-de-mama-con-afectacion-ganglionar-axilar","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/expresion-del-oncogen-her2-neu-p53-y-otros-factores-clinico-patologicos-en-el-cancer-de-mama-con-afectacion-ganglionar-axilar\/","title":{"rendered":"Expresion del oncogen her2\/neu, p53 y otros factores clinico-patologicos en el cancer de mama con afectacion ganglionar axilar."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Climent Duran Miguel Angel <\/strong><\/h2>\n<p>Se ha evaluado el valor pronostico de la sobreexpresion del oncogen her-2\/neu y de la proteina p53 determinadas por inmunohistoquimica y comparado con los factores clinico-patologicos convencionales, en 283 pacientes con afectacion ganglionar tratadas entre enero-1976 y diciembre 1986, en el hospital de san pau de barcelona.  el seguimiento medio es de 93 meses. El 23,4% de los tumores presentaron expresion de her-2\/neu y el 40% de p53. La sobreexpresion de p53 presento relacion significativa con el numero de ganglios axilares (p=0.03), la necrosis (0.03), los re(p=0.03) y rp(0.06).  no presento relacion significativa ni con la superviviencia libre de enfermedad (sle) ni la global (sg). La sobreexpresion de her-2\/neu presento relacion significativa con la el numero de ganglios afectos (p=0.04), el infiltrado linfoplasmocitico (p=0.00004), los re(p=0.003) y rp (p=0.01). En el analisis univariado para la sle presentaron significacion estatistica el numero de adenopatias afectas (p&lt;0.00001), la afectacion capsular granglionar (p&lt;0.00001), la infiltracion linfatica (p=0.0001), la diferenciacion tubular (p=0.01), el grado (p=0.02), el estado menopausico (p=0.02), la presencia de rp (p=0.03) y la sobreexpresion de her-2\/neu(p=0.05). El analisis multivario (cox) indico como factores independientes el numero de ganglios afectos (p&lt;0.00001), ausencia de rp (p=0.004), estado menopausico (p=0.005) y la permeacion linfatica (p=0.05).  en el analisis univariado para la sg presentacion significacion estadistica el numero de ganglios afectos (p&lt;0.00009), la diferenciacion tubular (p=0.0003), el grado (p=0.005), la edad (p=0.005), la edad (p=0.007), la sobreexpresion de her-2\/neu (p=0.02) y la ausencia de rp (p=0.04). En el analisis multivariado (cox) fueron factores independientes: el numero de ganglios afectos (p&lt;0.00001), la edad (p=004), el grado (p=0.04) y los rp (p=0.04). En el grupo de pacientes tratados con hormonoterapi<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Expresion del oncogen her2\/neu, p53 y otros factores clinico-patologicos en el cancer de mama con afectacion ganglionar axilar.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Expresion del oncogen her2\/neu, p53 y otros factores clinico-patologicos en el cancer de mama con afectacion ganglionar axilar. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Climent Duran Miguel Angel <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1996<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jaime Prat D\u00edaz De Losada<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Antonio Cardesa Garc\u00eda <\/li>\n<li>Ferran Guedea Edo (vocal)<\/li>\n<li>Antonio Gomez Gomez (vocal)<\/li>\n<li>Vicente Guillem Porta (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Climent Duran Miguel Angel Se ha evaluado el valor pronostico de la sobreexpresion del oncogen her-2\/neu y [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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