{"id":131044,"date":"1996-01-01T00:00:00","date_gmt":"1996-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-las-acciones-facilitadoras-e-inhibidoras-del-ondansetron-en-la-transmision-neuromuscular-del-ileon-de-cobaya\/"},"modified":"1996-01-01T00:00:00","modified_gmt":"1996-01-01T00:00:00","slug":"estudio-de-las-acciones-facilitadoras-e-inhibidoras-del-ondansetron-en-la-transmision-neuromuscular-del-ileon-de-cobaya","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/estudio-de-las-acciones-facilitadoras-e-inhibidoras-del-ondansetron-en-la-transmision-neuromuscular-del-ileon-de-cobaya\/","title":{"rendered":"Estudio de las acciones facilitadoras e inhibidoras del ondansetron en la transmision neuromuscular del ileon de cobaya."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Asensio Gonzalez Lartitegui <\/strong><\/h2>\n<p>El ondansetron, farmaco antiemetico de amplio uso, cuya accion se debe al antagonismo de la accion de la serotonina sobre los receptores 5ht3, afecta a la motilidad gastrointestinal a traves de un mecanismo desconocido. En este trabajo, se investigo la accion del ondansetron en el ileon aislado de cobaya. A concentraciones entre 10 elevado a menos 7 y 3&#215;10 elevado a menos 6 m el ondansetron se comporto como un antagonista 5-ht3 (pa2=7.33). A concentraciones entre 2&#215;10 elevado a menos 6 y 2&#215;10 elevado a menos 5 m, el ondansetron aumento la amplitud de las contracciones evocadas por estimulacion electrica submaximal en esta preparacion (de50=1.3&#215;10 elevado a menos 5 m). Este efecto no fue antagonizado por antagonistas 5ht3 ni 5ht4, ni emulado por otros antagonistas 5ht3. Dicho efecto desaparecio tras la desensibilizacion del tejido con serotonina o con 2-metilserotinina, por lo que debe estar mediado por un receptor de serotonina, probablemente el receptor 5ht1p. A concentraciones entre 2&#215;10 elevado a menos 5 y 2&#215;10 elevado a menos 4 m el ondansetron inhibio las contracciones inducidas por estimulacion electrica, aun en presencia de (-)naloxona o idazoxan. Ademas, el ondansetron a concentraciones estimulantes (10 elevado a menos 5 m) no altero la curva dosisrespuesta a la acetilcolina, pero disminuyo el efecto inhibidor de la morfina en esta preparacion biologica.  como conclusion, el ondansetron facilita la transmision neuromuscular excitadora en el ileon de cobaya activando receptores serotoninergicos diferentes a los 5ht3 o a los 5ht4, y la inhibe a concentraciones mayores a traves de un mecanismo independiente de los receptores opiaceos y los alfa-2 adrenergicos. Ademas, a concentraciones estimulantes, el ondansetron es capaz de modificar la accion de la morfina sobre la motilidad intestinal in vitro.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de las acciones facilitadoras e inhibidoras del ondansetron en la transmision neuromuscular del ileon de cobaya.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de las acciones facilitadoras e inhibidoras del ondansetron en la transmision neuromuscular del ileon de cobaya. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Asensio Gonzalez Lartitegui <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1996<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Puig De Conias Margarita M.<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Francesc Jan\u00e9 Carrenca <\/li>\n<li> Varga Alvarez Castellanos M. Luisa (vocal)<\/li>\n<li>LLuis CasaJuan a F. (vocal)<\/li>\n<li>Mar\u00eda  Isabel Loza Garcia (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Asensio Gonzalez Lartitegui El ondansetron, farmaco antiemetico de amplio uso, cuya accion se debe al antagonismo de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[160,35,561,5531,817,17],"tags":[134206,51,244760,9145,244758,244759],"class_list":["post-131044","post","type-post","status-publish","format-standard","hentry","category-bioquimica","category-ciencias-de-la-vida","category-farmacologia-molecular","category-fisiologia-gastrointestinal","category-fisiologia-humana","category-quimica","tag-asensio-gonzalez-lartitegui","tag-francesc-jane-carrenca","tag-lluis-casajuan-a-f","tag-maria-isabel-loza-garcia","tag-puig-de-conias-margarita-m","tag-varga-alvarez-castellanos-m-luisa"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/131044","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=131044"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/131044\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=131044"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=131044"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=131044"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}