{"id":131051,"date":"1996-01-01T00:00:00","date_gmt":"1996-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/glomerulosclerosis-y-colesterol\/"},"modified":"1996-01-01T00:00:00","modified_gmt":"1996-01-01T00:00:00","slug":"glomerulosclerosis-y-colesterol","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/glomerulosclerosis-y-colesterol\/","title":{"rendered":"Glomerulosclerosis y colesterol."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Sonia Higueruelo Demason <\/strong><\/h2>\n<p>El objetivo de nuestro trabajo consistio en estudiar el efecto del colesterol en la aparicion y la progresion de la glomerulosclerosis. Para ello se utilizaron 2 modelos experimentales: la nefrectomia unilateral en rata sprague-dawley y la rata zucker obesa. Asimismo, considerando que la expansion mesangial es una caracteristica comun a diferentes nefropatias que suele preceder al desarrollo de la lesion glomerular, se evaluo el efecto in vivo y\/o in vitro de 3 estrategias terapeuticas: el suplemento dietetico con pufas-w3 y el tratamiento con iecas e inhibidores del enzima hmg-coa reductasa. Tambien estudiamos la implicacion de la angiotensina ii en la proliferacion de las celulas mesangiales en cultivo.  en la rata sprague-dawley, la dieta hipercolesterolemica produjo dislipemia, proteinuria y la aparicion de lesiones glomerulares focales y segmentarias. En la rata zucker, el colesterol provoco la acumulacion de celulas espumosas en el mesangio glomerular. En ambos modelos se modifico el patron de sintesis y secrecion de eicosanoides glomerulares. La nefrectomia y las caracteristicas de las zucker obesas acentuaron los efectos citados. In vivo, el tratamiento con pufas-w3 y con fosinopril redujo la progresion de la lesion glomerular. In vitro, la pravastatina y el fosinopril disminuyeron la proliferacion mesangial. Ademas la angiotensina ii se relaciono con la expansion mesangial al incrementar la sintesis de proteinas y la proliferacion mesangial inducida por el pdgf-bb y el suero en cultivos glomerulares y de celulas mesangiales respectivamente.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Glomerulosclerosis y colesterol.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Glomerulosclerosis y colesterol. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Sonia Higueruelo Demason <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1996<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Ram\u00f3n Romero  Gonz\u00e1lez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Celestino Rey-joly Barroso <\/li>\n<li>Ricardo Pujol Borrell (vocal)<\/li>\n<li>Juan Rubies Prat (vocal)<\/li>\n<li>Alejandro Darnell Tey (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Sonia Higueruelo Demason El objetivo de nuestro trabajo consistio en estudiar el efecto del colesterol en la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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