{"id":131089,"date":"1996-01-01T00:00:00","date_gmt":"1996-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/cambios-adaptativos-en-la-estructura-subcelular-del-diafragma-humano-asociaciones-con-la-enfermedad-pulmonar-obstructiva-cronica\/"},"modified":"1996-01-01T00:00:00","modified_gmt":"1996-01-01T00:00:00","slug":"cambios-adaptativos-en-la-estructura-subcelular-del-diafragma-humano-asociaciones-con-la-enfermedad-pulmonar-obstructiva-cronica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/cambios-adaptativos-en-la-estructura-subcelular-del-diafragma-humano-asociaciones-con-la-enfermedad-pulmonar-obstructiva-cronica\/","title":{"rendered":"Cambios adaptativos en la estructura subcelular del diafragma humano: asociaciones con la enfermedad pulmonar obstructiva cronica."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mauricio Orozco Levi <\/strong><\/h2>\n<p>La hiperinsuflacion pulmonar deteriora la funcion del diafragma en pacientes con enfermedad pulmonar obstructiva cronica (epoc). Sin embargo, un reciente estudio funcional sugiere que algunos cambios estructurales podrian suceder en el musculo como fenomenos compensatorios ante los efectos deletereos de la hiperinsuflacion.  objetivo: evaluar la eventual asociacion entre la funcion respiratoria y la estructura subcelular del diafragma en seres humanos.  materia y metodos: se estudiaron 33 pacientes varones (63+-9 a\u00f1os) que fueron llevados a toracotomia por neoplasia pulmonar de peque\u00f1o tama\u00f1o. Previo al acto quirurgico se evaluaron el estado nutricional y la funcion respiratoria y de los musculos respiratorios. Se tomaron biopsias del diafragma costal que fueron procesadas para analisis histoquimico y de microscopia electronica.  resultados: los pacientes mostraron un volumen espiratorio forzado en el 1er segundo (fev1) de 73+-15% ref; presion inspiratoria maxima (plmax), 108+-39%ref; volumen de gas intratoracico (itgv), 118+-31%ref; volumen residual\/capacidad pulmonar total (rv\/tlc), 43+-12%; y presion transdiafragmatica maxima, 93.8+-29.8 cmh2o. El analisis morfometrico de la estructura subcelular mostro una densidad mitocondrial (dmit) de 56+-17 mitocondrias\/100um2, depositos de glicogeno (%glic), 9.6+-4.4% del area celular, y longitud de las sarcomeras (lsar), 2.15+-17 um. La obstruccion del flujo aereo se asocio con una mayor dmit y los volumenes pulmonares estadisticos con una menor lsar (p&lt;0.05, ambos). Ademas, la dmit correlaciono con la obstruccion al flujo aereo (con fev1, r=0.57, p&lt;0.01), y la fuerza de los musculos inspiratorios (con plmax, r=0.57, p&lt;0.01). Por su parte lsar correlaciono con el itgv (r= 4,72, p&lt;0.05) y el atrapamiento aereo (%rv\/tlc, r =0.57, p&lt;0.01). El % glic no correlaciono con ninguna de las variables funcionales.  conclusiones: este estudio demuestra que existe una asociaci<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Cambios adaptativos en la estructura subcelular del diafragma humano: asociaciones con la enfermedad pulmonar obstructiva cronica.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Cambios adaptativos en la estructura subcelular del diafragma humano: asociaciones con la enfermedad pulmonar obstructiva cronica. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mauricio Orozco Levi <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1996<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Joaquin Gea Guiral<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Joaquin Sanchis Aldas <\/li>\n<li>Robert Rodr\u00edguez Roisin (vocal)<\/li>\n<li>Sergio Serrano Figueras (vocal)<\/li>\n<li>Dario Maldonado Gomez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mauricio Orozco Levi La hiperinsuflacion pulmonar deteriora la funcion del diafragma en pacientes con enfermedad pulmonar obstructiva 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