{"id":131098,"date":"1996-01-01T00:00:00","date_gmt":"1996-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/animales-transgenicos-que-expresan-interferon-beta-en-el-pancreas-un-modelo-para-el-estudio-de-la-etiopatogenia-de-la-diabetes-mellitus\/"},"modified":"1996-01-01T00:00:00","modified_gmt":"1996-01-01T00:00:00","slug":"animales-transgenicos-que-expresan-interferon-beta-en-el-pancreas-un-modelo-para-el-estudio-de-la-etiopatogenia-de-la-diabetes-mellitus","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/animales-transgenicos-que-expresan-interferon-beta-en-el-pancreas-un-modelo-para-el-estudio-de-la-etiopatogenia-de-la-diabetes-mellitus\/","title":{"rendered":"Animales transgenicos que expresan interferon-beta en el pancreas: un modelo para el estudio de la etiopatogenia de la diabetes mellitus."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mireia Pelegrin Zurilla <\/strong><\/h2>\n<p>La diabetes mellitus es una de las enfermedades metabolicas mas frecuentes en medicina humana con una incidencia en la poblacion mundial del 6%. Clinicamente la diabetes mellitus se ha clasificado en dos tipos: la diabetes mellitus dependiente de insulina o iddm y la diabetes mellitus no dependiente de insulina o niddm.  la iddm, es el resultado de la destruccion de las celulas productoras de insulina, o celulas beta, localizadas en los islotes pancreaticos de langerhans. La destruccion de las celulas beta esta asociada a una infiltracion mononuclear de los islotes que comporta una marcada hipoinsulinemia y la consecuente aparicion de hiperglucemia. Hasta el momento, no se conoce la causa de la enfermedad, aunque se postula que es un proceso autoinmune en el cual se encuentran implicados factores tanto geneticos (genes propios del huesped) como ambientales (infecciones virales).  existen diversas evidencias que sugieren una asociacion entre las infecciones virales y la aparicion de la iddm.  asi, se ha postulado en multiples ocasiones que la produccion de citoquinas inducida por infecciones o bien por la accion de alguna substancia toxica podria estar involucrada en el desarrollo de la enfermedad.  el objetivo de este trabajo ha sido utilizar las nuevas tecnolog\u00edas de transferencia de genes para la obtencion de un animal trangenico que exprese interferon beta (ifn-beta) en las celulas beta del pancreas, con la finalidad de dilucidar cual es la implicacion de esta citoquina en la instauracion del proceso diabetico. Para se ha construido un gen quimerico formado por la fusion del promotor del gen de la insulina de rata i (rip i) a un fragmento del gen del ifn-beta humano.  los resultados obtenidos este estudio indican que la presencia constante de esta citoquina en los islotes pancreaticos tiene como consecuencia una alteracion funcional de las celulas beta productoras de insulina que comporta alteraciones a nivel sistemico en<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Animales transgenicos que expresan interferon-beta en el pancreas: un modelo para el estudio de la etiopatogenia de la diabetes mellitus.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Animales transgenicos que expresan interferon-beta en el pancreas: un modelo para el estudio de la etiopatogenia de la diabetes mellitus. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mireia Pelegrin Zurilla <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1996<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Alfons Valera Abril<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Joaqu\u00edn Ari\u00f1o Carmona <\/li>\n<li>Pedro Lazo (vocal)<\/li>\n<li>Lisardo Bosc\u00e1 Gomar (vocal)<\/li>\n<li>Vicente Aige Gil (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mireia Pelegrin Zurilla La diabetes mellitus es una de las enfermedades metabolicas mas frecuentes en medicina humana [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[849,160,115,35,9224,17],"tags":[244829,6619,5664,244828,171748,197231],"class_list":["post-131098","post","type-post","status-publish","format-standard","hentry","category-biologia-celular","category-bioquimica","category-bioquimica-molecular","category-ciencias-de-la-vida","category-citogenetica","category-quimica","tag-alfons-valera-abril","tag-joaquin-arino-carmona","tag-lisardo-bosca-gomar","tag-mireia-pelegrin-zurilla","tag-pedro-lazo","tag-vicente-aige-gil"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/131098","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=131098"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/131098\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=131098"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=131098"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=131098"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}