{"id":131190,"date":"1996-01-01T00:00:00","date_gmt":"1996-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-experimental-sobre-las-alteraciones-hemodinamicas-y-morfologicas-precoces-en-corazon-de-ratas-espontaneamente-hipertensas-sin-tratamiento\/"},"modified":"1996-01-01T00:00:00","modified_gmt":"1996-01-01T00:00:00","slug":"estudio-experimental-sobre-las-alteraciones-hemodinamicas-y-morfologicas-precoces-en-corazon-de-ratas-espontaneamente-hipertensas-sin-tratamiento","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-experimental-sobre-las-alteraciones-hemodinamicas-y-morfologicas-precoces-en-corazon-de-ratas-espontaneamente-hipertensas-sin-tratamiento\/","title":{"rendered":"Estudio experimental sobre las alteraciones hemodinamicas y morfologicas precoces en corazon de ratas espontaneamente hipertensas sin tratamiento."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ricardo Cabrera Sole <\/strong><\/h2>\n<p>Hipotesis: la hipertension arterial ocasiona cambios hemodinamicos y morfologicos en el corazon en fase precoz de su evolucion.Objetivos: evaluar las alteraciones hemodinamicas y morfologicas precoces en corazon de ratas espontaneamente hipertensas (shr) sin tratamiento.Material y metodos: se estudiaron 25 ratas shr comparadas con 2k ratas consanguineas normotensas de la cepa wystar-kioto (wky), de 17 sem. De edad y 350 gr.  de peso, que fueron sometidos a mediciones no invasivas de tension arterial en cola y a cateterismo cardiaco valorandose los sgts., Parametros: tension arterial sistolica, diastolica y media, frec. Cardiaca (fc), presiones maxima, minima y al final de la diastole del ventriculo izdo. (Lvedp), gasto cardiaco (gc), volumen de eyeccion sistolico (ves) y la dp\/dt maxima y minima para valorar la distensibilidad de vi. Morfologicamente se evaluaron: peso del vi, numero de celulas cardiacas, espesor de pared de vasos sanguineos (epv), diametro de la luz de los vasos y tejido intersticial.  resultados: se demostro diferencias estadisticamente significativas entre ambos grupos en la tension arterial sistolica, diastolica y media medidas tanto por medio no invasivs como por cateterismo. El gc, el ves y la distensibilidad diastolica del vi estaban disminuidos significativamente en el grupo shr. El espesor de pared vascular era mayor en el grupo shr. El numero de miocitos era mayor en el grupo wky. Los demas parametros evaluados no mostraron diferencis estadisticamente significativas.  conclusiones: las alteraciones hemodinamicas mas precoces en corazon de ratas shr son la disminucion de la distensibilidad diastolica del vi, y la disminucion del gc y del ves.  &#8211; el aumento del espesor de la pared vascular y la hipertrofia celular cardiaca son las alteraciones morfologicas mas precoces en aparecer en el corazon de ratas shr comparada  con las wky.  implicaciones clinicas: la alteracion en la relajacion diastolica del<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio experimental sobre las alteraciones hemodinamicas y morfologicas precoces en corazon de ratas espontaneamente hipertensas sin tratamiento.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio experimental sobre las alteraciones hemodinamicas y morfologicas precoces en corazon de ratas espontaneamente hipertensas sin tratamiento. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ricardo Cabrera Sole <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1996<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Manuel Oya Otero<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan  Jos\u00e9 V\u00e1zquez Rodr\u00edguez <\/li>\n<li>Manuel Luque Otero (vocal)<\/li>\n<li>Jaime Merino Sanchez (vocal)<\/li>\n<li> Lopez-fando De Castro Javier (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ricardo Cabrera Sole Hipotesis: la hipertension arterial ocasiona cambios hemodinamicos y morfologicos en el corazon en fase [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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