{"id":13128,"date":"2001-03-10T00:00:00","date_gmt":"2001-03-10T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/analisis-de-la-actividad-telomerasa-en-tumores-humanos-correlacion-con-otras-alteraciones-moleculares-y-parametros-cla%c2%adnicos\/"},"modified":"2001-03-10T00:00:00","modified_gmt":"2001-03-10T00:00:00","slug":"analisis-de-la-actividad-telomerasa-en-tumores-humanos-correlacion-con-otras-alteraciones-moleculares-y-parametros-cla%c2%adnicos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/analisis-de-la-actividad-telomerasa-en-tumores-humanos-correlacion-con-otras-alteraciones-moleculares-y-parametros-cla%c2%adnicos\/","title":{"rendered":"An\u00e1lisis de la actividad telomerasa en tumores humanos. correlaci\u00f3n con otras alteraciones moleculares y par\u00e1metros cl\u00ednicos."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Rosa Gonz\u00e1lez-quevedo Alvarez <\/strong><\/h2>\n<p>La reactivaci\u00f3n de la telomerasa es una alteraci\u00f3n gen\u00e9tica muy frecuente en c\u00e9lulas tumorales, habi\u00e9ndose encontrado actividad de dicha enzima en aproximadamente un 80% de los tumores humanos. Sin embargo, en la mayor parte de los tejidos normales no se detecta, hecho que ha despertado grandes expectativas en cuanto a su potencial como marcador pron\u00f3stico, diagn\u00f3stico y como diana en la terapia anticancer\u00edgena. En el presente trabajo hemos analizado la actividad de dicha enzima en una poblaci\u00f3n de 266 muestras patol\u00f3gicas y en sus correspondientes controles de tejido normal, encontrando que, efectivamente, m\u00e1s de un 80% presentaron reactivaci\u00f3n de la misma. la actividad telomerasa ha demostrado ser un factor de mal pron\u00f3stico en nuestra poblaci\u00f3n de tumores no microc\u00edticos de pulm\u00f3n, y conferir tendencia a dicho pron\u00f3stico adversa pacientes afectados de tumores colorrectales.Adem\u00e1s, hemos encontrado que la expresi\u00f3n de la prot\u00e9ian supresora de tumores p16, constituye un factor protecot en los pacientes afectados de tumores de pulm\u00f3n con actividad telomerasa positiva. En esta poblaci\u00f3n de pacientes de pulm\u00f3n, tambi\u00e9n hemos estudiado la expresi\u00f3n de la oncoproteina c-myc, que ha demostrado ser un factor pron\u00f3stico independiente de estadio. Asimismo,hemos analizado las p\u00e9rdidas de heterocigosidad en el brazo corto del cromosoma 3, encontrando que se trata de una alteraci\u00f3n molecular frecuente en carcinomas  de pulm\u00f3n y colorrectales. En concreto, las p\u00e9rdidas al\u00e9licas en el marcador d3s1260 confieren un pron\u00f3stico adverso a los pacientes afectados de ambas patolog\u00edas. Nuestros datos moleculares pueden ser de gran utilidad a nivel cl\u00ednico ya que permitir\u00e1n establecer grupos de pacientes con mayor riesgo de sufrir recidivas tumorales y que puedan beneficiarse de protocolos terap\u00e9uticos m\u00e1s adecuados.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>An\u00e1lisis de la actividad telomerasa en tumores humanos. correlaci\u00f3n con otras alteraciones moleculares y par\u00e1metros cl\u00ednicos.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 An\u00e1lisis de la actividad telomerasa en tumores humanos. correlaci\u00f3n con otras alteraciones moleculares y par\u00e1metros cl\u00ednicos. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Rosa Gonz\u00e1lez-quevedo Alvarez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 03\/10\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Iniesta Serrano Mar\u00eda Pilar<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Antonio  jose Torres Garc\u00eda <\/li>\n<li>Santiago Ramon y cajal ag\u00ed\u00bceras (vocal)<\/li>\n<li>Mar\u00eda Cascales angosto (vocal)<\/li>\n<li>Mar\u00eda antonia Blasco marhuenda (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Rosa Gonz\u00e1lez-quevedo Alvarez La reactivaci\u00f3n de la telomerasa es una alteraci\u00f3n gen\u00e9tica muy frecuente en c\u00e9lulas tumorales, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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