{"id":131282,"date":"1996-01-01T00:00:00","date_gmt":"1996-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudios-in-vitro-de-la-proteolisis-del-precursor-de-la-proteina-beta-amiloide-de-la-enfermedad-de-alzheimer-y-de-su-interaccion-con-la-apolipoproteina-e\/"},"modified":"1996-01-01T00:00:00","modified_gmt":"1996-01-01T00:00:00","slug":"estudios-in-vitro-de-la-proteolisis-del-precursor-de-la-proteina-beta-amiloide-de-la-enfermedad-de-alzheimer-y-de-su-interaccion-con-la-apolipoproteina-e","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/estudios-in-vitro-de-la-proteolisis-del-precursor-de-la-proteina-beta-amiloide-de-la-enfermedad-de-alzheimer-y-de-su-interaccion-con-la-apolipoproteina-e\/","title":{"rendered":"Estudios \u00abin vitro\u00bb de la proteolisis del precursor de la proteina beta-amiloide de la enfermedad de alzheimer y de su interaccion con la apolipoproteina e."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Cristina Haas Sevilla <\/strong><\/h2>\n<p>En este trabajo se ha puesto  a punto un sistema experimental para la expresion y purificacion de la proteina beta-app y para la identificacion directa de los fragmentos generados por la proteolisis \u00abin vitro\u00bb de esta proteina. Asimismo, se ha demostrado que la beta-app es sustrato del factor de coagulacion xa, identificando cortes especificos dentro de su secuencia, se ha caracterizado tambien la pauta de fragmentacion proteolitica de la beta-app generada por diferentes proteasas que han sido implicadas en la patogenesis de la enfermedad, observando que los patrones de fragmentacion pueden ser alterados en presencia de un entorno lipidico.  finalmente se ha demostrado la formacion de complejos estables y resistentes a sds entre la apolipoproteina e y la beta-app, que podrian preceder o regular la deposicion del peptido beta-amiloide:<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudios \u00abin vitro\u00bb de la proteolisis del precursor de la proteina beta-amiloide de la enfermedad de alzheimer y de su interaccion con la apolipoproteina e.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudios \u00abin vitro\u00bb de la proteolisis del precursor de la proteina beta-amiloide de la enfermedad de alzheimer y de su interaccion con la apolipoproteina e. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Cristina Haas Sevilla <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1996<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jes\u00fas Vazquez Cobos<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jes\u00fas Avila De Grado <\/li>\n<li>Carlos Gabriel De Miguel Vazquez (vocal)<\/li>\n<li>Juan  Antonio Reig Maci\u00e1 (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Cristina Haas Sevilla En este trabajo se ha puesto a punto un sistema experimental para la expresion [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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