{"id":131300,"date":"1996-01-01T00:00:00","date_gmt":"1996-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-expresion-y-funcion-de-las-integrinas-vla-1-y-vla-4-en-el-infiltrado-inflamatorio-sinovial-de-la-artritis-reumatoide\/"},"modified":"1996-01-01T00:00:00","modified_gmt":"1996-01-01T00:00:00","slug":"estudio-de-la-expresion-y-funcion-de-las-integrinas-vla-1-y-vla-4-en-el-infiltrado-inflamatorio-sinovial-de-la-artritis-reumatoide","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-de-la-expresion-y-funcion-de-las-integrinas-vla-1-y-vla-4-en-el-infiltrado-inflamatorio-sinovial-de-la-artritis-reumatoide\/","title":{"rendered":"Estudio de la expresion y funcion de las integrinas vla-1 y vla-4 en el infiltrado inflamatorio sinovial de la artritis reumatoide."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Armando Laff\u00f3n Roca <\/strong><\/h2>\n<p>El infiltrado inflamatorio de la membrana sinovial de pacientes con artritia reumatoide (ar) se caracteriza, entre otros fenomenos, por presentar abundantes linfocitos t de fenotipo cooperador. Es evidente que estos linfocitos migran atravesando la capa de celulas endoteliales de los vasos hacia la membrana sinovial, donde juegan un papel esencial en los procesos de destruccion articular tipicos de la ar. Para que este fenomeno suceda se precisa la actuacion de diversas moleculas de adhesion que a traves de pares ligando\/receptor realicen la diapedesis linfocitaria y el anclaje posterior a proteinas de matriz extracelular.  este trabajo describe la existencia de subpoblaciones de linfocitos t vla-1+ y vla-4+ en la membrana y liquido sinovial de ar. Desde el punto de vista funcional, los linfocitos vla 4+ tienen un claro incremento en su capacidad de adhesion a sus ligandos naturales: vcam-1 presente en celulas endoteliales y fragmento cs-1 de fibronectina presente en matriz extracelular.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la expresion y funcion de las integrinas vla-1 y vla-4 en el infiltrado inflamatorio sinovial de la artritis reumatoide.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la expresion y funcion de las integrinas vla-1 y vla-4 en el infiltrado inflamatorio sinovial de la artritis reumatoide. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Armando Laff\u00f3n Roca <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1996<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Francisco Sanchez Madrid<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Manuel Ortiz De Landazuri <\/li>\n<li> Gomez-reino Carnota Juan  Jos\u00e9 (vocal)<\/li>\n<li>Carlos Martinez Alonso (vocal)<\/li>\n<li>Pedro Sabando Suarez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Armando Laff\u00f3n Roca El infiltrado inflamatorio de la membrana sinovial de pacientes con artritia reumatoide (ar) se [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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