{"id":131362,"date":"1996-01-01T00:00:00","date_gmt":"1996-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/significado-biologico-de-la-cuantificacion-de-citocinas-urinarias-en-la-inmunoterapia-de-los-carcinomas-superficiales-de-vejiga\/"},"modified":"1996-01-01T00:00:00","modified_gmt":"1996-01-01T00:00:00","slug":"significado-biologico-de-la-cuantificacion-de-citocinas-urinarias-en-la-inmunoterapia-de-los-carcinomas-superficiales-de-vejiga","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/significado-biologico-de-la-cuantificacion-de-citocinas-urinarias-en-la-inmunoterapia-de-los-carcinomas-superficiales-de-vejiga\/","title":{"rendered":"Significado biologico de la cuantificacion de citocinas urinarias en la inmunoterapia de los carcinomas superficiales de vejiga."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Carlos Olivier Gomez <\/strong><\/h2>\n<p>Este trabajo, para obtar al grado de doctor, analiza la naturaleza de la reaccion inflamatoria de la pared vesical, en los carcinomas de celulas transicionales de localizacion vesical, valoranda a traves de la cuantificacion de diversas citocinas en la orina.En el estudio se incluyen los resultados obtenidos en la cuantificacion de il-1, il-2, il-4, il-6 ifn-y e tnf-alfa en muestras de orina correspondientes a 45 pacientes diagnosticados de carcinoma de celulas transicionales superficiales, de localizacion vesical, sometidos a diferentes tratamientos con inmunomoduladores de la respuesta biologica (bcg e ifnalfa-2b) o a quimioterapia (mmc), en ambos casos, mediante instilaciones intracavitarias de los diferentes farmacos y en regimen adyuvante a la cirugia de las lesiones macroscopicamente visibles. Simultaneamente se estudiaron como controles 20 sujetos donantes sanos, 10 pacientes con carcinoma de celulas transicionales infiltrantes y 10 pacientes con infecciones del tracto urinario.  los resultados obtenidos en este estudio demuestran que las concentraciones urinarias de il-1, il-2, il-6, tnf-alfa y ifn-gamma en los cct-s, previamente a larealizacion de algun tratamiento profilactico intracavitario, son similares a las encontradas en sujetos sanos y significativamente inferiores a las de los pacientes con infeccion urinaria; y que en los pacientes con cct infiltrante la concentracion urinaria de la il-6 es significativamente superior a la de los que presentaban cct-s. Los niveles de il-4 urinaria no manifiestan diferencias entre los cct-s y los grupos control.  con respecto a la inmunoprofilaxis con bcg se ha objetivado que su instilacion vesical, en los pacientes con cct-s, provoca un aumento significativo de los niveles urinarios de las il-2, il-1, il-6 y el tnf-alfa que se revela desde las primeras horas (0-8 h). Ademas, las concentraciones urinarias de las il-1 e il-6 permanecen elevadas tras las instilaciones repetidas<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Significado biologico de la cuantificacion de citocinas urinarias en la inmunoterapia de los carcinomas superficiales de vejiga.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Significado biologico de la cuantificacion de citocinas urinarias en la inmunoterapia de los carcinomas superficiales de vejiga. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Carlos Olivier Gomez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1996<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Joaquin Carballido Rodr\u00edguez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Castillo Olivares Jos\u00e9 Luis <\/li>\n<li>Jos\u00e9 Cabrera Marin (vocal)<\/li>\n<li>Juan  Manuel Bell\u00f3n Caneiro (vocal)<\/li>\n<li>Manuel Rodriguez Zapata (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Carlos Olivier Gomez Este trabajo, para obtar al grado de doctor, analiza la naturaleza de la reaccion [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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