{"id":131427,"date":"1996-01-01T00:00:00","date_gmt":"1996-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/utilidad-potencial-de-la-calcitonina-como-radiofarmaco-en-el-estudio-de-la-patologia-osea\/"},"modified":"1996-01-01T00:00:00","modified_gmt":"1996-01-01T00:00:00","slug":"utilidad-potencial-de-la-calcitonina-como-radiofarmaco-en-el-estudio-de-la-patologia-osea","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/utilidad-potencial-de-la-calcitonina-como-radiofarmaco-en-el-estudio-de-la-patologia-osea\/","title":{"rendered":"Utilidad potencial de la calcitonina como radiofarmaco en el estudio de la patolog\u00eda osea."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Pedro Manuel Uriarte Gonzalez <\/strong><\/h2>\n<p>La unica tecnica gammagrafica especificamente dirigida al estudio del hueso es la gammagrafia con fosfonatos. El estudio gammagrafico de densidad de receptores podria ser un metodo util de exploracion del metabolismo oseo. En particular, tendria interes el estudio de los receptores osteoclasticos de calcitonina, ya que parece haber relacion entre la expresion de este receptor y la actividad osteoclastos.  el presente trabajo tiene por objeto investigar la utilidad potencial de la calcitonina como radiofarmaco para el estudio del metabolismo oseo, estudiando su cinetica (plasmatica y en sangre total), eliminacion (urinaria y fecal), su distribucion en condiciones normales (cuantitativa y cualitativa mediante autorradiografia) y en un modelo patologico (dieta hipocalcica).  el estudio se ha realizado empleando calcitonina de salmon marcada con i-125 y ratas macho de raza sprague-dawley.  la cinetica plasmatica y la sanguinea presentan perfiles muy semejantes, que se ajustan a un modelo tricompartimental abierto y sugieren la existencia de una rapida disposicion de la calcitonina, intenso metabolismo de la misma y lenta eliminacion de sus metabolitos.  la eliminacion se produce fundamentalmente por via urinaria en las primeras 24 horas. La eliminacion fecal es escasa.  los organos que presentan mayor concentracion de radiactividad a los 40 min son el tiroides, los ri\u00f1ones, los huesos y el musculo esqueletico. El deposito renal es particularmente intenso en la capa cortical y disminuye rapidamente, lo que sugiere intensa reabsorcion tubular y metabolizacion con liberacion de los metabolitos a la sangre. El deposito oseo es intenso en las areas de mayor actividad metabolica -cartilagos de crecimiento, metafisis y periostio- y aumenta en los animales sometidos a dieta hipocalcica, que es un estimulo para la reabsorcion osteoclastica. El deposito en los musculos puede deberse a la existencia en ellos de receptores de alta afinid<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Utilidad potencial de la calcitonina como radiofarmaco en el estudio de la patolog\u00eda osea.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Utilidad potencial de la calcitonina como radiofarmaco en el estudio de la patolog\u00eda osea. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Pedro Manuel Uriarte Gonzalez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1996<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jes\u00fas Santamaria Martin<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Mart\u00ednez L\u00f3pez De Letona Juan <\/li>\n<li>Jos\u00e9 Luis Carreras Delgado (vocal)<\/li>\n<li>Juan  Emilio Feliu Albi\u00f1ana (vocal)<\/li>\n<li> Morcillo Alonso Miguel Angel (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Pedro Manuel Uriarte Gonzalez La unica tecnica gammagrafica especificamente dirigida al estudio del hueso es la gammagrafia [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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