{"id":131445,"date":"1996-01-01T00:00:00","date_gmt":"1996-01-01T00:00:00","guid":{"rendered":""},"modified":"1996-01-01T00:00:00","modified_gmt":"1996-01-01T00:00:00","slug":"estudio-del-efecto-citoprotector-de-los-farmacos-calcio-antagonistas-en-el-modelo-de-isquemia-cerebral-global-en-el-jerbo-y-en-el-modelo-de-citoxicidad-por-veratridina-en-celulas-cromafines-bovinas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-del-efecto-citoprotector-de-los-farmacos-calcio-antagonistas-en-el-modelo-de-isquemia-cerebral-global-en-el-jerbo-y-en-el-modelo-de-citoxicidad-por-veratridina-en-celulas-cromafines-bovinas\/","title":{"rendered":"Estudio del efecto citoprotector de los farmacos calcio-antagonistas en el modelo de isquemia cerebral global en el jerbo y en el modelo de citoxicidad por veratridina en celulas cromafines bovinas."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Pedro Zapater Hernandez <\/strong><\/h2>\n<p>Se realizo un estudio del efecto neuroprotector de los farmacos bloqueantes de los canales de ca2+ en dos modelos experimentales diferentes: en el modelo de isquemia cerebral global en el jerbo, donde los mecanismos y factores que influyen en el efecto del farmaco son numerosos (influencia vascular, complejidad del tejido cerebral, factores farmacocineticos, etc&#8230;)En el modelo de citotoxicidad por veratridina en celulas cromafines bovinas con el objeto de estudiar el mecanismo de accion concreto de cada farmaco, su dependencia de dosis y el posible efecto citotoxico atribuible al propio farmaco.  las conclusiones que se obtuvieron fueron:  1) la entrada del ca2+ en las neuronas es un factor fundamental para que se produzca la lesion celular en la situacion de isquemia. Los farmacos calcio-antagonistas interfieren en el desarrollo de dicha lesion.  2) el efecto neuroprotector de los farmacos calcio-antagonistas en la lesion isquemica cerebral es parcial y difiere segun las caracteristicas de de selectividad sobre distintos subtipos de canales de ca2+ y la dosis empleada.  3) los farmacos calcio-antagonistas que bloquean selectivamente un solo subtipo de canales de ca2+, aunque este represente una importante fraccion de la corriente global de ca2+, son poco eficaces para contrarrestar la lesion celular por ca2+.  4) las dihidropiridinas, bloqueantes selectivos de los canales l, muestran un efecto neuroprotector peque\u00f1o.  5) la flunarizina, calcio-antagonista no selectivo, es mas eficaz para prevenir la lesion isquemica cerebral que las dihidropiridinas, pero con un rango terapeutico mas estrecho.  6) el efecto toxico de la flunarizina es un efecto directo sobre las neuronas.  7) la busqueda de un farmaco con capacidad de bloquear el mayor numero posible de subtipos de canales de ca2+ sin afectar a otras estructuras celulares puede significar un avance en el tratamiento de la lesion neuronal que causa la isquemia, siempr<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio del efecto citoprotector de los farmacos calcio-antagonistas en el modelo de isquemia cerebral global en el jerbo y en el modelo de citoxicidad por veratridina en celulas cromafines bovinas.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio del efecto citoprotector de los farmacos calcio-antagonistas en el modelo de isquemia cerebral global en el jerbo y en el modelo de citoxicidad por veratridina en celulas cromafines bovinas. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Pedro Zapater Hernandez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1996<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio Garcia Garcia<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Pedro S\u00e1nchez Garc\u00eda <\/li>\n<li>Jos\u00e9 Roda Frade (vocal)<\/li>\n<li>Ricardo Borges Jurado (vocal)<\/li>\n<li>Valent\u00edn Ce\u00f1a Callejo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Pedro Zapater Hernandez Se realizo un estudio del efecto neuroprotector de los farmacos bloqueantes de los canales [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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