{"id":131729,"date":"1996-01-01T00:00:00","date_gmt":"1996-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/tamoxifeno-en-mujeres-con-cancer-de-mama-efectos-sobre-el-metabolismo-oseo\/"},"modified":"1996-01-01T00:00:00","modified_gmt":"1996-01-01T00:00:00","slug":"tamoxifeno-en-mujeres-con-cancer-de-mama-efectos-sobre-el-metabolismo-oseo","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/tamoxifeno-en-mujeres-con-cancer-de-mama-efectos-sobre-el-metabolismo-oseo\/","title":{"rendered":"Tamoxifeno en mujeres con cancer de mama: efectos sobre el metabolismo oseo."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Josefa Castro Martin <\/strong><\/h2>\n<p>Se dise\u00f1o un estudio prospectivo a 9 meses para comprobar el efecto de tamoxifeno sobre el metabolismo lipidico y oseo en mujeres postmenopausicas con cancer de mama. Se administraron 20 mg de tamoxifeno\/dia durante una media de 17.52+\/-14.94 meses en 51 mujeres, que se compararon con un grupo control de 52 mujeres canarias sanas, obtenidas del estudio multicentrico nacional para calcular los valores normales de masa osea en la mujer espa\u00f1ola. Consideramos criterios de exclusion la presencia de metastasis oseas, alteraciones del metabolismo oseo, condiciones patologicas o el empleo de farmacos con influencia sobre este y enfermedades que dificulten la medicion de masa osea.  se determinaron los parametros bioquimicos de metabolismo lipidico: colesterol total, trigliceridos, ldl-colesterol y hdl-colesterol, los parametros bioquimicos de metabolismo oseo: fosfatasa alcalina, osteocalcina, fosfatasa acida tartrato resistente en sangre, y calcio e hidroxiprolina en orina de 24 horas. Tambien se midio la densidad de masa osea (dmo) en columna lumbar (de l1 a l4) y femur proximal (cuello, trocanter, intertrocanter y triangulo de ward); todo ello al inicio y al final de un periodo de 9 meses de seguimiento.  resultados: no observamos ninguna variacion estadisticamente significativa entre los parametros de metabolismo oseo ni en la dmo en el grupo de estudio al final de los 9 meses de seguimiento. Objetivamos un descenso estadisticamente significativo de ldl- colesterol (de 118.20+\/-33.72 mg\/dl a 110.6+\/-32.15 mg\/dl) en el grupo de pacientes en tratamiento con tamoxifeno al cabo de los 9 meses (p&lt;0.05). Entre las mujeres mayores de 70 a\u00f1os del grupo de estudio, se objetivo una dmo de femur proximal mas alta (0.788+\/-0.024 g\/cm2) que en las pacientes de la misma edad del grupo control (0.701+\/- 0.026 g\/cm2), que fue estadisticamente significativa (p&lt;0.05), tanto al inicio como al final del estudio. Igualmente detectamos, en el<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Tamoxifeno en mujeres con cancer de mama: efectos sobre el metabolismo oseo.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Tamoxifeno en mujeres con cancer de mama: efectos sobre el metabolismo oseo. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Josefa Castro Martin <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Palmas de gran canaria<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1996<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Manuel Sosa Henr\u00edquez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Pedro Betancor Le\u00f3n <\/li>\n<li>Jos\u00e9 Aguiar Morales (vocal)<\/li>\n<li>Celestino Rey Solis (vocal)<\/li>\n<li> Piedra Concepcion De La (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Josefa Castro Martin Se dise\u00f1o un estudio prospectivo a 9 meses para comprobar el efecto de tamoxifeno [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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