{"id":13197,"date":"2001-08-10T00:00:00","date_gmt":"2001-08-10T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estres-quirurgico-citocinas-y-poblaciones-linfocitarias\/"},"modified":"2001-08-10T00:00:00","modified_gmt":"2001-08-10T00:00:00","slug":"estres-quirurgico-citocinas-y-poblaciones-linfocitarias","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estres-quirurgico-citocinas-y-poblaciones-linfocitarias\/","title":{"rendered":"Estr\u00e9s quir\u00fargico, citocinas y poblaciones linfocitarias"},"content":{"rendered":"<h2>Tesis doctoral de <strong> M. Dolores Ru\u00edz Romero De La Cruz <\/strong><\/h2>\n<p>Objetivo  estudiar la evoluci\u00f3n postoperatoria del balance th1\/th2 de la respuesta inmunol\u00f3gica frente a la cirug\u00eda ortop\u00e9dica major en base a los cambios de las poblaciones linfocitarias y de los niveles s\u00e9ricos de citocinas.  pacientes y m\u00e9todos  el grupo de referencia estuvo constituido por 20 donates sanos y los de estudio por 20 pacientes intervenidos de cirug\u00eda de columna lumbar cop y 20 pacientes sometidos a cirug\u00eda baja cec (cc) en los que se obtuvieron muestras perioperatorias de sangre, adem\u00e1s de datos cl\u00ednicos de sangrado, reposici\u00f3n hem\u00e1tica y complicaciones. En cada una de ellas se cuantificaron las poblaciones linfocitarias mediante citometr\u00eda de flujo (facscan, becton-dickinson), utilizando anticuerpos anti cd3, cd4, cd5, cd7, cd8, cd16, cd19, cd56, ra\/ro y cd25, y los niveles s\u00e9ricos de il1, il2, ill4, il5, il6, il10, il12, ifn y tnf (elisa, bender med systems), adem\u00e1s de una hermatimetr\u00eda completa (technicon h.3 rtx, bayer diagnostics).  resultados  en ambos tipos de cirug\u00eda se produjo un sangrado importane que oblig\u00f3 a la reposici\u00f3n hem\u00e1tica en el 90% de los pacientes, aunque la tasa reposici\u00f3n\/sangrado fue mayor en cop. Tras la cirug\u00eda se produce un aumento de los leucocitos totales, a costa de un aumento de pmn y una disminuci\u00f3n de diversas poblaciones linfocitarias, especialmente los lifnocitos t y sus subpoblaciones, aunque no se modificaron los cocientes ra\/ro ni cd4\/cd8 y las nk. En cop, se elevaron los niveles de il-6, mientras que en cc se elevaron adem\u00e1s los de il-10. los niveles de il1, il5, il8, e il12 no se modificaron y los de il2, il4, ifn y tnf estuvieron por debajo del l\u00edmite de detecci\u00f3n.  conclusiones  ambos tipos de cirug\u00eda inducen una linfopenia postoperatoria que afecta a todas las poblaciones linfocitarias, lo que junto con el tipo de citocinas circulantes sugieren la presencia de una respuesta inmunol\u00f3gica tipo th2 que, especialmente encop, a\u00fan persiste siete d<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estr\u00e9s quir\u00fargico, citocinas y poblaciones linfocitarias<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estr\u00e9s quir\u00fargico, citocinas y poblaciones linfocitarias <\/li>\n<li><strong>Autor:<\/strong>\u00a0 M. Dolores Ru\u00edz Romero De La Cruz <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 M\u00e1laga<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 08\/10\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Manuel Mu\u00f1oz Gomez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Miguel Morell oca\u00f1a <\/li>\n<li>ram\u00f3n Salinas argente (vocal)<\/li>\n<li>isidro Prat arrojo (vocal)<\/li>\n<li>Jos\u00e9 Mar\u00eda De pablos gallego (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de M. Dolores Ru\u00edz Romero De La Cruz Objetivo estudiar la evoluci\u00f3n postoperatoria del balance th1\/th2 de la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[160,2148,35,9,10615,195,1737,2612,7834,156,17],"tags":[42928,42929,42925,42926,2167,42927],"class_list":["post-13197","post","type-post","status-publish","format-standard","hentry","category-bioquimica","category-bioquimica-inmunologica","category-ciencias-de-la-vida","category-ciencias-medicas","category-estres","category-hemopatologia","category-inmunologia","category-inmunoquimica","category-malaga","category-patologia","category-quimica","tag-isidro-prat-arrojo","tag-jose-maria-de-pablos-gallego","tag-m-dolores-ruiz-romero-de-la-cruz","tag-manuel-munoz-gomez","tag-miguel-morell-ocana","tag-ramon-salinas-argente"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/13197","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=13197"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/13197\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=13197"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=13197"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=13197"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}