{"id":131983,"date":"1996-01-01T00:00:00","date_gmt":"1996-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/nuevos-derivados-heterociclicos-como-antagonistas-no-peptidicos-de-angiotensina-e-inhibidores-de-5-lipoxigenasa\/"},"modified":"1996-01-01T00:00:00","modified_gmt":"1996-01-01T00:00:00","slug":"nuevos-derivados-heterociclicos-como-antagonistas-no-peptidicos-de-angiotensina-e-inhibidores-de-5-lipoxigenasa","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/nuevos-derivados-heterociclicos-como-antagonistas-no-peptidicos-de-angiotensina-e-inhibidores-de-5-lipoxigenasa\/","title":{"rendered":"Nuevos derivados heterociclicos como antagonistas no peptidicos de angiotensina e inhibidores de 5-lipoxigenasa."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Francisca Delgado Jimenez <\/strong><\/h2>\n<p>En el primer apartado del trabajo se describe la preparacion de nuevos derivados antagonistas de angiotensina ii, que poseen en su estructura heterociclos de los siguientes tipo: 1h-nafto (2,3-d) imidazol, 1h-benzotriazol, 1h-nafto(2,3-d)(1,2,3) triazol, 1h- perimidina, 1h-nafto(1,8-de) (1,2,3) triazina, pirimidina y 2-aminoazinas y como sustituyentes en el n heterociclico sistemas derivados de bifenilo y feniltienilo sustituidos por un grupo carboxilico o un anillo de tetrazol. En la preparacion de los derivados de 2-aminoazina se han utilizado como precursores n-(2-azinil) aminidas de piridinio, su alquilacion regioselectiva en el nitrogeno iminico, halogenacion en condiciones suaves en las posiciones 3- y\/o 5- del anillo de azina y reduccion del enlace n-n sin alterar los enlaces c-x, permite preparar 2-aminoazinas, n-alquil-2-aminoazinas y 2-aminopiridinas mono- y dihalogenadas. En la segunda parte del trabajo, se comunica la preparacion de n-(2-azinil)aminoquinonas como inhibidores de 5-lipoxigenasa por reaccion de n-(2-azinil) aminidas de piridinio con las correspondientes quinonas. Finalmente se indican los resultados de los estudios farmacologicos llevados a cabo hasta el momento.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Nuevos derivados heterociclicos como antagonistas no peptidicos de angiotensina e inhibidores de 5-lipoxigenasa.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Nuevos derivados heterociclicos como antagonistas no peptidicos de angiotensina e inhibidores de 5-lipoxigenasa. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Francisca Delgado Jimenez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Alcal\u00e1<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1996<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>builla G\u00f3mez \u00e1lvarez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Rafael Suau Suarez <\/li>\n<li>Enrique D\u00edez Barra (vocal)<\/li>\n<li>Enrique Galvez Ruano (vocal)<\/li>\n<li>Carlos Sunkel (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Francisca Delgado Jimenez En el primer apartado del trabajo se describe la preparacion de nuevos derivados antagonistas [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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