{"id":132019,"date":"1996-01-01T00:00:00","date_gmt":"1996-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/analisis-clinico-y-genetico-del-trastorno-afectivo-bipolar\/"},"modified":"1996-01-01T00:00:00","modified_gmt":"1996-01-01T00:00:00","slug":"analisis-clinico-y-genetico-del-trastorno-afectivo-bipolar","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/analisis-clinico-y-genetico-del-trastorno-afectivo-bipolar\/","title":{"rendered":"Analisis clinico y genetico del trastorno afectivo bipolar."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Llinares Zaragoza M. Consuelo <\/strong><\/h2>\n<p>El problema de la heterogeneidad clinico-genetica del trastorno afectivo bipolar (tabp) ha sido el mayor reto al que se ha enfrentado la investigacion genetica de este transtorno. Pese a que se ha demostrado su base genetica, aun siguen sin clarificarte transtorno. Pese a que se ha su base genetica, aun siguen sin clarificarse los mecanismos geneticos subyacentes y tampoco se conoce con certeza el modo de transmision de la enfermedad.  en este trabajo, gracias a la homogenizacion de la poblacion de enfermos, se han encontrado resultados de asociacion genetica positiva del tabp de esta poblacion espa\u00f1ola con los polimorfismos de th (tirosina hidroxilasa) y drd2 (receptor dopaminergico d2), que ya habian sido considerados genes candidatos para el tabp; apoyando estos resultados la existencia de un modelo oligogenico donde th y drd2 serian genes menores de susceptibilidad para el tabp.  el estudio familiar, ademas de sustentar la tendencia familiar hereditaria del tabp y de favorecer la hipotesis de un continuum en los transtornos afectivos, ha permitido apoyar dos de los postulados modos de transmision de la enfermedad: el de la herencia ligada al cromosoma x y el del fenomeno de anticipacion genetica.  por otro lado, el estudio de las caracteristicas clinico-evolutivas: edad de inicio, gravedad de la enfermedad, respuesto al tratamiento, factores precipitantes, etc., Ha permitido establecer importantes relaciones entre la heterogeneidad clinica y la genetica del tabp.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Analisis clinico y genetico del trastorno afectivo bipolar.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Analisis clinico y genetico del trastorno afectivo bipolar. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Llinares Zaragoza M. Consuelo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Alcal\u00e1<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1996<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jeronimo Saiz Ruiz<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan  Jose Lopez-ibor Ali\u00f1o <\/li>\n<li>Jos\u00e9 Luis Ayuso Gutierrez (vocal)<\/li>\n<li>Julio Bobes (vocal)<\/li>\n<li>Alfonso Chinchilla Moreno (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Llinares Zaragoza M. Consuelo El problema de la heterogeneidad clinico-genetica del trastorno afectivo bipolar (tabp) ha sido [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[17426,9,1408],"tags":[14386,15315,1846,464,153952,245835],"class_list":["post-132019","post","type-post","status-publish","format-standard","hentry","category-alcala","category-ciencias-medicas","category-psiquiatria","tag-alfonso-chinchilla-moreno","tag-jeronimo-saiz-ruiz","tag-jose-luis-ayuso-gutierrez","tag-juan-jose-lopez-ibor-alino","tag-julio-bobes","tag-llinares-zaragoza-m-consuelo"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/132019","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=132019"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/132019\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=132019"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=132019"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=132019"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}