{"id":132157,"date":"1996-01-01T00:00:00","date_gmt":"1996-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-protector-de-los-antagonistas-del-calcio-en-el-dano-hepatico-producido-por-etanol\/"},"modified":"1996-01-01T00:00:00","modified_gmt":"1996-01-01T00:00:00","slug":"efecto-protector-de-los-antagonistas-del-calcio-en-el-dano-hepatico-producido-por-etanol","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/efecto-protector-de-los-antagonistas-del-calcio-en-el-dano-hepatico-producido-por-etanol\/","title":{"rendered":"Efecto protector de los antagonistas del calcio en el da\u00f1o hepatico producido por etanol."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Almudena Cobreros Bordenave <\/strong><\/h2>\n<p>Debido al importante papel que juega la regulacion de la concentracion de calcio en el hepatocito y a su posible implicacion en la hepatotoxicidad originada por diversas sustancias quimicas, se esta prestando gran atencion al posible papel protector de aquellas sustancias que interfieren con las vias de utilizacion del calcio, como los antagonistas del calcio farmacos objeto de nuestro estudio. En este trabajo se ha estudiado el papel protector de verapamil, nifedipina y diltiazem frente al da\u00f1o hepatico originado por etanol. Se han empleado modelos \u00abin vitro\u00bb (suspensiones de hepatocitos) e \u00abin vivo\u00bb. El etanol provocaba una aumento en las actividades enzimaticas alt, ast y ldh en hepatocitos aislados, que era tiempo y concentracion dependiente tambien se observo un aumento de la concentracion de calcio libre intracelular, que igualmente era dependiente de la concentracion de etanol.  los tres antagonistas de calcio, fundamentalmente nifedipina y diltiazem, redujeron las actividades enzimaticas, asi como la peroxidacion lipidica inducida por etanol 300 y 500 mm.  el estudio \u00abin vivo\u00bb se realizo tanto en modelos de intoxicacion etilica aguda como cronica se valoraron distintos parametros indicativos de lesion hepatica, observandose que el tratamiento con nifedipina, pero fundamentalmente con diltiazem producia una mejoria de dichos parametros.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto protector de los antagonistas del calcio en el da\u00f1o hepatico producido por etanol.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto protector de los antagonistas del calcio en el da\u00f1o hepatico producido por etanol. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Almudena Cobreros Bordenave <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1996<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Edurne Cenarruzabeitia Sagarminaga<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda  Pilar Fernandez Otero <\/li>\n<li>Francisco Zaragoza Garcia (vocal)<\/li>\n<li>Jos\u00e9 Mar\u00eda Calleja Suarez (vocal)<\/li>\n<li>Mar\u00eda  Lourdes Sainz Suberviola (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Almudena Cobreros Bordenave Debido al importante papel que juega la regulacion de la concentracion de calcio en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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