{"id":132171,"date":"1996-01-01T00:00:00","date_gmt":"1996-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-niveles-de-leucotrienos-en-pacientes-alergicos-y-su-correlacion-con-otros-parametros-inmunologicos\/"},"modified":"1996-01-01T00:00:00","modified_gmt":"1996-01-01T00:00:00","slug":"estudio-de-niveles-de-leucotrienos-en-pacientes-alergicos-y-su-correlacion-con-otros-parametros-inmunologicos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-de-niveles-de-leucotrienos-en-pacientes-alergicos-y-su-correlacion-con-otros-parametros-inmunologicos\/","title":{"rendered":"Estudio de niveles de leucotrienos en pacientes alergicos y su correlacion con otros parametros inmunologicos."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Marta Ferrer Puga <\/strong><\/h2>\n<p>Los sulfidoleucotrienos (slt) (ltc4, ltd4, y lte4) son mediadores lipidicos derivados del metabolismo oxidativo del acido araquidonico por accion de la 5-lipoxigenasa, con una potente capacidad broncoconstrictora, incrementan la permeabilidad vascular y la secrecion de moco. En este estudio hemos pretendido valorar la posible produccion y liberacion de slt tras estimulacion ag- especifica in vitro de leucocitos aislados de sangre periferica mediante la tecnica cast-elisa, en 92 pacientes con sensibilizacion comprobada a lolium y d. Pteronyssinus, y sus posibles modificaciones en funcion del grado de sensibilizacion, y caracteristicas clinicas, asi como la correlacion con la liberacion de otros mediadores como la histamina. Hemos observado una produccion ag- especifica de slt tras estimulo con lolium perenne y d.  pteronyssinus in vitro, que no se obtiene en condiciones basales, y es significativamente mayor en los pacientes atopicos que en controles sanos y controles atopicos no sensibles a estos alergenos. La concentracion optima para el alergeno lolium ha sido la de 2ng\/ml en nuestro estudio y de 20 ng\/ml para d. Pteronyssinus, con una gran variabilidad individual en la respuesta. Hemos verificado asi mismo que existe una produccion de slt estimulando con anti-ige monoclonal, que ademas es mayor en pacientes atopicos que en controles sanos. En la liberacion de histamina los resultados son semejantes, observando una correlacion significativa y positiva entre el test de liberacion de histamina y la tecnica cast para determinacion de slt. Existe una correlacion positiva y significativa entre la prueba cutanea y la tecnica cast.  finalmente, los pacientes sometidos a tratamiento inmunoterapico, han mostrado una produccion de slt y liberacion de histamina menor que aquellos que no lo venian siguiendo.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de niveles de leucotrienos en pacientes alergicos y su correlacion con otros parametros inmunologicos.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de niveles de leucotrienos en pacientes alergicos y su correlacion con otros parametros inmunologicos. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Marta Ferrer Puga <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1996<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda  Luisa Sanz Larruga<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Esteban Santiago Calvo <\/li>\n<li>Alberto Oehling Ruiz (vocal)<\/li>\n<li>Jos\u00e9 Bueno G\u00f3mez (vocal)<\/li>\n<li>Jorge  Antonio Guisantes Del Barco (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Marta Ferrer Puga Los sulfidoleucotrienos (slt) (ltc4, ltd4, y lte4) son mediadores lipidicos derivados del metabolismo oxidativo [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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