{"id":132178,"date":"1996-01-01T00:00:00","date_gmt":"1996-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/identificacion-de-determinantes-t-helper-en-la-proteina-del-core-del-virus-de-la-hepatitis-c-vhc-mediante-peptidos-sinteticos-correlacion-con-la-respuesta-al-tratamiento-con-interferon-alfa\/"},"modified":"1996-01-01T00:00:00","modified_gmt":"1996-01-01T00:00:00","slug":"identificacion-de-determinantes-t-helper-en-la-proteina-del-core-del-virus-de-la-hepatitis-c-vhc-mediante-peptidos-sinteticos-correlacion-con-la-respuesta-al-tratamiento-con-interferon-alfa","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/identificacion-de-determinantes-t-helper-en-la-proteina-del-core-del-virus-de-la-hepatitis-c-vhc-mediante-peptidos-sinteticos-correlacion-con-la-respuesta-al-tratamiento-con-interferon-alfa\/","title":{"rendered":"Identificacion de determinantes t helper en la proteina del core del virus de la hepatitis c (vhc) mediante peptidos sinteticos. correlacion con la respuesta al tratamiento con interferon alfa."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Garcia Granero Marquez Marta <\/strong><\/h2>\n<p>Se sintetizaron 52 tetradecapeptidos solapados en 10 aminoacidos que abarcaban toda la secuencia de la proteina del core del virus de la hepatitis c (vhc) correspondiente a los genotipos del virus la y lb. Estos peptidos se usaron para caracterizar las respuestas humoral y t helper en ratones inmunizados con proteina recombinante y en pacientes con hepatitis cronica c que mostraron diferentes pautas de respuesta al tratamiento con interferon alfa (ifn). Los pacientes que respondieron al tratamiento con ifn reconocieron un numero superior de peptidos de la proteina del core del vhc como determinantes t helper que los pacientes no respondedores y que los no tratados. Los peptidos representados por los aminoacidos 99-112 y 132-145 (correspondientes a dos zonas altamente conservadas de la proteina del core) fueron los mejor reconocidos por los pacientes respondedores al tratamiento con ifn. Estos dos peptidos podrian ser candidatos a formar parte de una vacuna sintetica contra el vhc.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Identificacion de determinantes t helper en la proteina del core del virus de la hepatitis c (vhc) mediante peptidos sinteticos. correlacion con la respuesta al tratamiento con interferon alfa.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Identificacion de determinantes t helper en la proteina del core del virus de la hepatitis c (vhc) mediante peptidos sinteticos. correlacion con la respuesta al tratamiento con interferon alfa. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Garcia Granero Marquez Marta <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1996<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Francisco Borras Cuesta<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jes\u00fas M. Prieto Valtue\u00f1a <\/li>\n<li>Mar\u00eda  Jes\u00fas Lopez Zabalza (vocal)<\/li>\n<li>Ignacio Jos\u00e9 Encio Martinez (vocal)<\/li>\n<li>Luis EnJuan es Sanchez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Garcia Granero Marquez Marta Se sintetizaron 52 tetradecapeptidos solapados en 10 aminoacidos que abarcaban toda la secuencia [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1738,35,1737,17749,280,14141],"tags":[18184,246011,18279,15059,5594,18030],"class_list":["post-132178","post","type-post","status-publish","format-standard","hentry","category-antigenos","category-ciencias-de-la-vida","category-inmunologia","category-navarra","category-virologia","category-virus-viscerotropicos","tag-francisco-borras-cuesta","tag-garcia-granero-marquez-marta","tag-ignacio-jose-encio-Martinez","tag-jesus-m-prieto-valtuena","tag-luis-enjuan-es-sanchez","tag-maria-jesus-lopez-zabalza"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/132178","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=132178"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/132178\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=132178"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=132178"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=132178"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}