{"id":132265,"date":"1996-01-01T00:00:00","date_gmt":"1996-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/proteinas-granulares-del-eosinofilo-en-el-asma-bronquial\/"},"modified":"1996-01-01T00:00:00","modified_gmt":"1996-01-01T00:00:00","slug":"proteinas-granulares-del-eosinofilo-en-el-asma-bronquial","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/proteinas-granulares-del-eosinofilo-en-el-asma-bronquial\/","title":{"rendered":"Proteinas granulares del eosinofilo en el asma bronquial."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Antonio Parra Arrondo <\/strong><\/h2>\n<p>La patogenicidad del eosinofilo esta determinada por sus proteinas especificas de los granulos secundarios, cuya liberacion es especifica segun el estimulo aplicado. En este estudio se evaluaron las variaciones sericas en los niveles de proteina cationica del eosinofilo y peroxidasa del eosinofilo en diferentes estadios de asma bronquial, extrinseco e intrinseco, y su correlacion con otros parametros de seguimiento como son la historia clinica, la espirometria, el numero de eosinofilos y un score global de asma. En una segunda parte del trabajo se valoro la liberacion de ecp in vitro por parte de eosinofilos de pacientes alergicos al dermatophagoides pteronyssinus, de forma basal o tras distintos estimulos, especificos (d. Pteronyssinus) e inespecificos (il-5, anti-ige y anti-igg), y en distintos tiempos de incubacion (30 y 360 minutos). Los niveles sericos de ambas proteinas granulares se encuentran significativamente elevados en pacientes respecto a controles. Existen diferencias significativas entre los distintos grados de severidad, asi como entre asmaticos activos respecto a silentes, y su elevacion es independiente de la etiolog\u00eda del asma. Sus valores se correlacionan con otros parametros de seguimiento como son el score, los valores espirometricos y la cifra de eosinofilos. La liberacion in vitro de estas proteinas es mayor en pacientes respecto a controles, y es dependiente del tiempo de incubacion, siendo significativamente mayor en los pacientes a las 6 horas. La il-5 influye significativamente en la liberacion de la misma, no asi la incubacion con d. Pteronyssinus. La liberacion de ecp en esas condiciones no parece depender especificamente del estimulo aplicado. Concluimos que la determinacion de proteinas granulares del eosinofilo es potencialmente util en la monitorizacion de los procesos alergicos.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Proteinas granulares del eosinofilo en el asma bronquial.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Proteinas granulares del eosinofilo en el asma bronquial. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Antonio Parra Arrondo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1996<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda  Luisa Sanz Larruga<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Esteban Santiago Calvo <\/li>\n<li>Alberto Oehling Ruiz (vocal)<\/li>\n<li>Jos\u00e9 Bueno G\u00f3mez (vocal)<\/li>\n<li>Jorge  Antonio Guisantes Del Barco (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Antonio Parra Arrondo La patogenicidad del eosinofilo esta determinada por sus proteinas especificas de los granulos secundarios, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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