{"id":132305,"date":"1996-01-01T00:00:00","date_gmt":"1996-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/farmacocinetica-de-distribucion-y-eliminacion-de-la-lomefloxacina-en-el-vitreo-de-conejo\/"},"modified":"1996-01-01T00:00:00","modified_gmt":"1996-01-01T00:00:00","slug":"farmacocinetica-de-distribucion-y-eliminacion-de-la-lomefloxacina-en-el-vitreo-de-conejo","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/farmacocinetica-de-distribucion-y-eliminacion-de-la-lomefloxacina-en-el-vitreo-de-conejo\/","title":{"rendered":"Farmacocinetica de distribucion y eliminacion de la lomefloxacina en el vitreo de conejo."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Eduardo Segura Rodriguez <\/strong><\/h2>\n<p>Los estudios farmacocineticos de farmacos a nivel ocular son muy escasos por la dificultad que plantea la toma de muestras a este nivel. Por otra parte, en los trabajos que han ido apareciendo se ha observado que con las vias de administracion habitualmente empleados, sistemica, topica y subconjuntival no se alcanzan niveles terapeuticos de farmaco en el vitreo, por lo que muchos de los tratamientos se realizan de forma empirica. Ha quedado establecido la liposolubidad favorece la entrada intraocular de los farmacos tras administracion sistemica. Por lo que se ha supuesto que el farmaco empleado, la lomefloxacina, altamente lipofilico, podria alcanzar en vitreo concentraciones terapeuticas tras su administracion intravenosa. El objetivo de este trabajo ha sido determinar los niveles intravitreos del farmaco tras su administracion sistemica para tres diferentes dosis, 10,20 y 50 mg por kg y establecer su farmacocinetica tras la inyeccion directa de una dosis de 250 ng en la cavidad vitrea. Se ha observado que los niveles en vitreo aumentan en relacion directa con la dosis y alcanzan unos valores de 0,47, 0,87 y 2,24 ng por ml maximos. El modelo monocompartimental es el que define el comportamiento del farmaco.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Farmacocinetica de distribucion y eliminacion de la lomefloxacina en el vitreo de conejo.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Farmacocinetica de distribucion y eliminacion de la lomefloxacina en el vitreo de conejo. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Eduardo Segura Rodriguez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1996<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Daniel Fos Galve<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Carlos Pastor Jimeno <\/li>\n<li> Molina Martinez Irene Teresa (vocal)<\/li>\n<li>Alfredo Orts Buch\u00f3n (vocal)<\/li>\n<li>Mar\u00eda Del Carmen Dios Vi\u00e9itez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Eduardo Segura Rodriguez Los estudios farmacocineticos de farmacos a nivel ocular son muy escasos por la dificultad [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[155,9,2445,957,17749,988],"tags":[19378,12341,246142,12508,51408,81670],"class_list":["post-132305","post","type-post","status-publish","format-standard","hentry","category-ciencias-clinicas","category-ciencias-medicas","category-evaluacion-de-farmacos","category-farmacologia","category-navarra","category-oftalmologia","tag-alfredo-orts-buchon","tag-daniel-fos-galve","tag-eduardo-segura-rodriguez","tag-jose-carlos-pastor-jimeno","tag-maria-del-carmen-dios-vieitez","tag-molina-Martinez-irene-teresa"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/132305","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=132305"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/132305\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=132305"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=132305"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=132305"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}