{"id":13247,"date":"2001-11-10T00:00:00","date_gmt":"2001-11-10T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/analisis-de-los-linfocitos-t-durante-el-periodo-perinatal\/"},"modified":"2001-11-10T00:00:00","modified_gmt":"2001-11-10T00:00:00","slug":"analisis-de-los-linfocitos-t-durante-el-periodo-perinatal","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/analisis-de-los-linfocitos-t-durante-el-periodo-perinatal\/","title":{"rendered":"Analisis de los linfocitos t durante el periodo perinatal"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Eva Jimenez Perez <\/strong><\/h2>\n<p>Nuestro trabajo ha pretendido estudiar la condicion especial de los linfocitos t durante el periodo perinatal y los mecanismos subyacentes que la explican, centrandose en dos aspectos concretos: el cambio de la ratio cd4:cd8 periferica que ocurre en este periodo, y la caracterizacion de las primeras celulas t que aparecen en los organos linfoides perifericos. con respecto al primer punto, nuestros resultados demuestran el origen timico de las distintas ratios cd4:cd8 perifericas encontradas a lo largo del desarrollo. La producci\u00f3n diferencial de timocitos cd4 y cd8 durante los periodos fetal y adulto est\u00e1 regulada por el estroma timico presumiblemente a traves de la distinta actividad, entre otras, de las moleculas de la familia notch y sus ligandos en estos estadios. Sin embargo, el rapido proceso perinatal que media el cambio de la ratio fetal a la adulta esta potenciado adem\u00e1s por diferencias en la tasa proliferativa de los timocitos cd4 y cd8, y por la migraci\u00f3n selectiva de las celulas cd8 a la periferia. por otro lado, la caracteristica mas sorprendente de la poblacion t periferica perinatal es la presencia de altos porcentajes de linfocitos cd4+cd8a+b+- tcrab hi con alta expresi\u00f3n de cd25, que son exportados por el tipo de manera preferencial durante este periodo. Sus caracteristicas fenotipicas los relacionan con los linfocitos cd4 y sus caracteristicas funcionales son: escasa sensibilidad a sufrir muerte mediada por glucocorticoides, y capacidad de proliferacion tras tratamiento con il2, al igual que los sp, pero presentan una baja respuesta a la estimulacion via cd3-tcr en relacion con los sp^, causada por su escasa capacidad de produccion de il2. Nuestro estudio nos permite concluir, ademas, que los dp perifericos son celulas inmaduras en proceso de diferenciaci\u00f3n, tanto fenotipica como funcional, a celulas cd4 de manera independiente del timo.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Analisis de los linfocitos t durante el periodo perinatal<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Analisis de los linfocitos t durante el periodo perinatal <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Eva Jimenez Perez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 11\/10\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Agustin Gregorio Zapata Gonzalez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda  monica De la fuente del rey <\/li>\n<li> Dominguez juncal fco Javier (vocal)<\/li>\n<li>Alberto Jos\u00e9 Villena cortes (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Eva Jimenez Perez Nuestro trabajo ha pretendido estudiar la condicion especial de los linfocitos t durante el [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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