{"id":13250,"date":"2001-11-10T00:00:00","date_gmt":"2001-11-10T00:00:00","guid":{"rendered":""},"modified":"2001-11-10T00:00:00","modified_gmt":"2001-11-10T00:00:00","slug":"muerte-de-las-celulas-ganglionares-de-la-retina-inducida-por-la-ligadura-transitoria-de-los-vasos-oftalmicos-prevencion-de-la-muerte-neuronal-con-sustancias-antiapoptoticas-y-agonistas-selectivos-de","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/muerte-de-las-celulas-ganglionares-de-la-retina-inducida-por-la-ligadura-transitoria-de-los-vasos-oftalmicos-prevencion-de-la-muerte-neuronal-con-sustancias-antiapoptoticas-y-agonistas-selectivos-de\/","title":{"rendered":"Muerte de las c\u00e9lulas ganglionares de la retina inducida por la ligadura transitoria de los vasos oft\u00e1lmicos. prevenci\u00f3n de la muerte neuronal con sustancias antiapopt\u00f3ticas y agonistas selectivos de receptores adren\u00e9rgicos alfa-2."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda Lafuente L\u00f3pez-herrera <\/strong><\/h2>\n<p>La supervivencia de la cgr tras la isquemia retiniana inducida por ligadura selectiva de los vasos oft\u00e1lmicos se determin\u00f3 en ratas adultas sprague-dawley, en las que la retina izquierda se someti\u00f3  a periodos de isquemia transitoria de 30,45,60,90 \u00f3 120 minutos de duraci\u00f3n. Los animales fueron analizados a los 5,14,21,60,60,90 \u00f3 180 d\u00edas de inducir estos periodos transitorios de isquemia y la supervivencia de las cgr se estim\u00f3 contando, sobre montajes globales de la retina, el n\u00famero de cgr marcadas retr\u00f3gradamente con el neurotrazador diasp, aplicado tres d\u00edas antes el proceso del animal en el mu\u00f1\u00f3n ocular del nervio \u00f3ptico (no) seccionado intraorbitariamente. en este estudio observamos que la muerte de las cgr tras la isquemia transitoria era un fen\u00f3meno progresivo. La muerte de cgr ten\u00eda una duraci\u00f3n de 14 d\u00edas cuando la isquemia transitoria inducida era de 30 \u00f3 45 minutos y se prolongaba hasta los 90 d\u00edas cuando la isquemia transitoria era de 60,90 \u00f3 120 minutos. tras periodos de isquemia de 30 \u00f3 45 minutos se produc\u00eda la muerte de un 46% \u00f3 50%, respectivamente, de la poblaci\u00f3n de cgr. Los porcentajes de muerte neuronal aumentaban a un 75%,87% \u00f3 99% tras periodos de isquemia de 60,90 \u00f3 120 minutos, respectivamente. As\u00ed, de este estudio concluimos que la muerte de ls cgr tras la isquemia retiniana es un fen\u00f3meno progresivo, cuya duraci\u00f3n y severidad depende de la duraci\u00f3n del per\u00edodo de isquemia inicial.  posteriormente, investigamos si la muerte de cgr inducida por la isquemia podr\u00eda prevenirse con la administraci\u00f3n de distintas sustancias neuroprotectoras, antes o despu\u00e9s de diferentes periodos de isquemia transitoria. Las cgr se marcaron con el trazador fluorescente fluoro-gold aplicado en ambos col\u00edculos superiores (css) 7 d\u00edas antes de inducir la isquemia retiniana. las sustancias empeladas fueron: el factor neurotr\u00f3fico derivado del cerebro (bdnf), la prote\u00edna bcl-2, el inhibidor de caspasas<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Muerte de las c\u00e9lulas ganglionares de la retina inducida por la ligadura transitoria de los vasos oft\u00e1lmicos. prevenci\u00f3n de la muerte neuronal con sustancias antiapopt\u00f3ticas y agonistas selectivos de receptores adren\u00e9rgicos alfa-2.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Muerte de las c\u00e9lulas ganglionares de la retina inducida por la ligadura transitoria de los vasos oft\u00e1lmicos. prevenci\u00f3n de la muerte neuronal con sustancias antiapopt\u00f3ticas y agonistas selectivos de receptores adren\u00e9rgicos alfa-2. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda Lafuente L\u00f3pez-herrera <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Murcia<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 11\/10\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Manuel Vidal Sanz<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Carlos Belmonte mart\u00ednez <\/li>\n<li>david Hicks (vocal)<\/li>\n<li>m. Bray garth (vocal)<\/li>\n<li> Lozano teruel Jos\u00e9 Antonio (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Lafuente L\u00f3pez-herrera La supervivencia de la cgr tras la isquemia retiniana inducida por ligadura selectiva de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[155,35,9,8235,4275,988],"tags":[8829,43090,8312,43091,7462,43089],"class_list":["post-13250","post","type-post","status-publish","format-standard","hentry","category-ciencias-clinicas","category-ciencias-de-la-vida","category-ciencias-medicas","category-murcia","category-neurociencias","category-oftalmologia","tag-carlos-belmonte-Martinez","tag-david-hicks","tag-lozano-teruel-jose-antonio","tag-m-bray-garth","tag-manuel-vidal-sanz","tag-maria-lafuente-lopez-herrera"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/13250","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=13250"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/13250\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=13250"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=13250"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=13250"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}