{"id":13273,"date":"2018-03-09T08:59:29","date_gmt":"2018-03-09T08:59:29","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efectos-de-la-administracion-local-y-sistemica-de-antioxidantes-en-el-sa%c2%adndrome-de-isquemia-reperfusion-estudio-experimental\/"},"modified":"2018-03-09T08:59:29","modified_gmt":"2018-03-09T08:59:29","slug":"efectos-de-la-administracion-local-y-sistemica-de-antioxidantes-en-el-sa%c2%adndrome-de-isquemia-reperfusion-estudio-experimental","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/efectos-de-la-administracion-local-y-sistemica-de-antioxidantes-en-el-sa%c2%adndrome-de-isquemia-reperfusion-estudio-experimental\/","title":{"rendered":"Efectos de la administraci\u00f3n local y sist\u00e9mica de antioxidantes en el s\u00edndrome de isquemia-reperfusi\u00f3n. estudio experimental"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Fernando Lopez Mozos <\/strong><\/h2>\n<p>La isquemia-reperfusi\u00f3n intestinal conlleva una serie de cambios metab\u00f3licos e histol\u00f3gicos que afectan al resto de \u00f3rganos de la econom\u00eda. Uno de los fen\u00f3menos que se producen es el del estr\u00e9s oxidativo.  objetivo  el objetivo de nuestro trabajo es analizar el efecto de la administraci\u00f3n aguda, portal y sist\u00e9mica, de antioxidantes tras la isquemia-reperfusi\u00f3n intestinal.  material y m\u00e9todos  dise\u00f1o experimental donde se han utilizado la administraci\u00f3n de vitamina c a dosis de 0,1 y 2 mmol\/kg. Y \u00e1cido lipoico a dosis de 20 y 100 mg\/kg. se han determinado los siguientes par\u00e1metros de estr\u00e9s oxidativo: super\u00f3xido dismutasa, catalasa, glutation-peroxidasa, glutation reducido, aglutation reducido, glutationoxidado, malonialdeh\u00eddo y 8-oh-dg. Estos par\u00e1metros han sido determinados en plasma, intestino, h\u00edgado, ri\u00f1\u00f3n y pulm\u00f3n.  resultados  se comprob\u00f3 una disminuci\u00f3n significativa de los sistemas antioxidantes y del glutation, as\u00ed como una elevaci\u00f3n de los productos de peroxidaci\u00f3n en todos los \u00f3rganos. Se evidenci\u00f3 un menor consumo o una mayor regeneraci\u00f3n del sistema enzim\u00e1tico y del glutation, as\u00ed como una disminuci\u00f3n de los productos de peroxidaci\u00f3n en todos los \u00f3rganos cuando se administraba antioxidantes respecto a los grupos control. Tambi\u00e9n se observ\u00f3 una dosis-dependencia del efecto antioxidante para ambas sustancias. As\u00ed como no se evidenciaron diferencias significativas ente ambas v\u00edas de administraci\u00f3n, portal y sist\u00e9mica.  conclusiones  existe una disminuci\u00f3n del da\u00f1o oxidativo generado tras la isquemia-reperfusi\u00f3n intestinal tras la administraci\u00f3n aguda de antioxidantes. Esta reducci\u00f3n del da\u00f1o es efectiva en el \u00f3rgano diana y en los \u00f3rganos a distancia.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efectos de la administraci\u00f3n local y sist\u00e9mica de antioxidantes en el s\u00edndrome de isquemia-reperfusi\u00f3n. estudio experimental<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efectos de la administraci\u00f3n local y sist\u00e9mica de antioxidantes en el s\u00edndrome de isquemia-reperfusi\u00f3n. estudio experimental <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Fernando Lopez Mozos <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 15\/10\/2001<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Salvador Lledo Matoses<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: eduardo (secretario) Garcia granero ximenez <\/li>\n<li>Francisco Sanchez bueno (vocal)<\/li>\n<li>  (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Fernando Lopez Mozos La isquemia-reperfusi\u00f3n intestinal conlleva una serie de cambios metab\u00f3licos e histol\u00f3gicos que afectan al [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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