{"id":132782,"date":"1997-01-01T00:00:00","date_gmt":"1997-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/modulacion-farmacologica-de-canales-de-calcio-y-receptores-nicotinicos-en-la-celula-cromafin-bovina\/"},"modified":"1997-01-01T00:00:00","modified_gmt":"1997-01-01T00:00:00","slug":"modulacion-farmacologica-de-canales-de-calcio-y-receptores-nicotinicos-en-la-celula-cromafin-bovina","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/modulacion-farmacologica-de-canales-de-calcio-y-receptores-nicotinicos-en-la-celula-cromafin-bovina\/","title":{"rendered":"Modulacion farmacologica de canales de calcio y receptores nicotinicos en la celula cromafin bovina."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Fernandez Fernandez Jos\u00e9 Manuel <\/strong><\/h2>\n<p>Este trabajo estudia el efecto que una serie de farmacos derivados del emopamil (e-5462, e-5608, e-5336 y e-5414), ejercen sobre los canales de ca2+ dependientes de voltaje de las celulas cromafines bovinas. Tales farmacos, a una concentracion de 10     m bloquearon de manera potente los canales de ca2+ dependientes de voltaje de estas celulas y los procesos de secrecion de catecolaminas y atp inducidos por un estimulo despolarizante, que consistio en la exposicion de las celulas cromafines a una elevada concentracion de k+ extracelular. Asimismo, se estudio el efecto de bloqueantes del sistema de recaptacion de catecolaminas u1 (imipramina, desipramina y nisoxetina) sobre la secrecion de catecolaminas y atp inducida por la activacion del receptor nicotinico en la celula cromafin bovina. Imipramina y desipramina bloquearon el proceso secretor inducido por nicotina 10 m, de manera dependiente de la concentracion, pudiendose explicar dicho bloqueo por un efecto directo sobre el receptor nicotinico y sobre los canales de ca2+ dependientes de voltaje. El efecto bloqueante de nisoxetina sobre la secrecion de catecolaminas podria explicarse por un bloqueo de la funcion del ionoforo asociado al receptor nicotinico.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Modulacion farmacologica de canales de calcio y receptores nicotinicos en la celula cromafin bovina.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Modulacion farmacologica de canales de calcio y receptores nicotinicos en la celula cromafin bovina. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Fernandez Fernandez Jos\u00e9 Manuel <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Alicante<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1997<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Valent\u00edn Ce\u00f1a Callejo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jose Serrano <\/li>\n<li>Julio Cortijo (vocal)<\/li>\n<li>Albert Badia Sancho (vocal)<\/li>\n<li>Jos\u00e9 Francisco Horga De La Parte (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Fernandez Fernandez Jos\u00e9 Manuel Este trabajo estudia el efecto que una serie de farmacos derivados del emopamil [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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