{"id":132813,"date":"1997-01-01T00:00:00","date_gmt":"1997-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudios-estructurales-y-funcionales-del-receptor-nicotinico-de-acetilcolina-en-distintos-estados-de-agregacion\/"},"modified":"1997-01-01T00:00:00","modified_gmt":"1997-01-01T00:00:00","slug":"estudios-estructurales-y-funcionales-del-receptor-nicotinico-de-acetilcolina-en-distintos-estados-de-agregacion","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/estudios-estructurales-y-funcionales-del-receptor-nicotinico-de-acetilcolina-en-distintos-estados-de-agregacion\/","title":{"rendered":"Estudios estructurales y funcionales del receptor nicotinico de acetilcolina en distintos estados de agregacion."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Elena Lopez Alonso <\/strong><\/h2>\n<p>A lo largo de este trabajo se ha conseguido purificar la forma monomerica del acchr procedente del organo electrico de \u00abt.Marmorata\u00bb a partir de la forma dimerica nativa sin inducir modificaciones estructurales importantes en el resto de la molecula. Unicamente se ha reducido el puente disulfuro responsable del dimero, por lo que no se han producido modificaciones en la estabilidad de la proteina frente a la desnaturalizacion termica. Ambas formas moleculares conservan sus propiedades funcionales ya que se desensibilizan en presencia continuada de agonista y responden al agonista traslocando iones en la escala de tiempo fisiologica. Las diferencias observadas entre ambas formas moleculares se basan en un menor incremento de afinidad a consecuencia de la desensibilizacion en la forma reducida, acompa\u00f1ado de una menor afinidad por los agonistas. A nivel de canal unico el dimero parece presentar una enorme de cooperatividad en cuanto a la apertura y cierre de los dos monomeros que lo forman dando la impresion de un unico canal. Este hecho parece representar un importante ejemplo de cooperatividad en un sistema biologico.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudios estructurales y funcionales del receptor nicotinico de acetilcolina en distintos estados de agregacion.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudios estructurales y funcionales del receptor nicotinico de acetilcolina en distintos estados de agregacion. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Elena Lopez Alonso <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Alicante<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1997<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Manuel Gonzalez Ros<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Joaqu\u00edn Rueda Puente <\/li>\n<li>Africa De Madariaga De Las Heras (vocal)<\/li>\n<li> Merch\u00e1n Cifuentes Jaime A. (vocal)<\/li>\n<li>Marcial Llanillo Ortega (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Elena Lopez Alonso A lo largo de este trabajo se ha conseguido purificar la forma monomerica del [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[19166,160,3178,17],"tags":[19030,246711,19433,24267,22470,19460],"class_list":["post-132813","post","type-post","status-publish","format-standard","hentry","category-alicante","category-bioquimica","category-proteinas","category-quimica","tag-africa-de-madariaga-de-las-heras","tag-elena-lopez-alonso","tag-joaquin-rueda-puente","tag-jose-manuel-gonzalez-ros","tag-marcial-llanillo-ortega","tag-merchan-cifuentes-jaime-a"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/132813","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=132813"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/132813\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=132813"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=132813"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=132813"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}