{"id":132870,"date":"1997-01-01T00:00:00","date_gmt":"1997-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-del-metabolismo-de-cafeina-en-neonatos\/"},"modified":"1997-01-01T00:00:00","modified_gmt":"1997-01-01T00:00:00","slug":"estudio-del-metabolismo-de-cafeina-en-neonatos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-del-metabolismo-de-cafeina-en-neonatos\/","title":{"rendered":"Estudio del metabolismo de cafeina en neonatos."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Eulogio Agulla Rodi\u00f1o <\/strong><\/h2>\n<p>Objetivos: estudio de la variabilidad y principales vias metabolicas del metabolismo oxidativo de cafeina en neonatos prematuros. Influencia de la maduracion y factores clinico-ambientales.  material y metodos: se han estudiado 60 recien nacidos prematuros de 24 a 35 semanas de edad gestacional ( 30,5+-2,6), que recibieron tratamiento con cafeina, tras la dosis de carga. De ellos, 34 fueron estudiados nuevamente a los 15 dias de tratamiento. Se determino la concentracion urinaria de cafeina y sus metabolitos por cromatografia liquida del alta presion, en orina de 24 horas.  resultados: cafeina fue la sustancia predominante en orina, en ambas fases del estudio. La variabilidad en la eliminacion urinaria de metabolitos fue superior al 80%.  teofilina fue el metabolito predominante en la fase inicial y paraxantina lo fue en la segunda. Los pacientes mayores de 6 dias y los que recibieron alimentacion metabolizaron mas cafeina. Los pacientes mas graves presentaron mayor actividad del enzima xantina oxidasa.  conclusiones: la demetilacion oxidativa de cafeina esta inmadura en la poblacion estudiada y presenta una gran variabilidad. La edad postnatal y la postconcepcional son los mejores predictores de la maduracion del metabolismo, el aumento de este se relaciono significativamente con el aporte de aminoacidos por via parenteral. La via n7 demetilacion fue predominante el primer dia de tratamiento, transcurridas dos semanas con el mismo, la via n3 demetilacion pasa a ser la mas importante, la via n1 permanece con muy escasa actividad.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio del metabolismo de cafeina en neonatos.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio del metabolismo de cafeina en neonatos. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Eulogio Agulla Rodi\u00f1o <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Extremadura<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1997<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Julio Benitez Rodriguez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Vicente Castells Ripoll <\/li>\n<li>Jos\u00e9 Mar\u00eda Ladero Quesada (vocal)<\/li>\n<li>Juan  Jos\u00e9 Cardesa Garc\u00eda (vocal)<\/li>\n<li>Jos\u00e9 Augusto Garc\u00eda-ag\u00fandez P\u00e9rez-coca (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Eulogio Agulla Rodi\u00f1o Objetivos: estudio de la variabilidad y principales vias metabolicas del metabolismo oxidativo de cafeina [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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